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Molecular and Cellular Biology of Bone, Part A
These volumes differ from the current conventional texts on bone cell biology. Biology itself is advancing at breakneck speed and many presentations completely fail to present the field in a truly modern context. This text does not attempt to present detailed clinical descriptions. Rather, after discussion of basic concepts, there is a concentration on recently developed findings equally relevant to basic research and a modern understanding of metabolic bone disease. The book will afford productive new insights into the intimate inter-relation of experimental findings and clinical understanding. Modern medicine is founded in the laboratory and demands of its practitioners a broad scientific understanding: these volumes are written to exemplify this approach. This book is likely to become essential reading equally for laboratory and clinical scientists.
Ion Channel Drug Discovery
A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.
Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition
Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Anatomy, Physiology, Metabolism, Morphology, and Human Biology. The editors have built Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anatomy, Physiology, Metabolism, Morphology, and Human Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Inhibition of Matrix Metalloproteinases
This volume comprises papers that deal with strategies of matrix metalloproteinases (MMPs), which have been implicated in human disease. These enzymes, including collagenase, gelatinase and stomelysin, appear to be pathologically increased in a wide variety of disease states such as rheumatoid and osteoarthritis, periodontal disease, diabetes, ophthalmologic conditions, neoplasia, dermatologic disorders, metabolic bone disease, and orthopedic conditions. Indentification of agents that might inhibit collagenase and other MMPs has been a therapeutic goal for modulation of connective tissue degradation. In view of the wide range of potential MMP inhibitors and the diversity of theoretically useful agents, experts from multidisciplinary fields discuss mechanisms of action and models for drug development.
Trafficking of Cardiac Ion Channels
Protein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesio...
Amylin
Amylin deciphers amylin's physiology and reveals previously unrecognized mechanisms fundamental to control body weight and fuel homeostasis. This book also discusses therapeutic utility of amylin as the first new medicine to treat diabetes since insulin. Provides a current comprehensive treatment of amylin the hormone Identifies the majority of amylin's physiologic functions
Clinical MR Neuroimaging
The physiological magnetic resonance techniques of diffusion imaging, perfusion imaging and spectroscopy offer insights into brain structure, function and metabolism. Until recently, they were mainly applied within the realm of medical research, but with their increasing availability on clinical MRI machines, they are now coming into clinical practice for the evaluation of neuropathology in individual patients. This book provides the reader with a thorough review of the underlying physical principles of each of these methods, as well as comprehensive coverage of their clinical applications. Topics covered include single- and multiple-voxel MRS techniques, MR perfusion based on both arterial spin labelling and dynamic bolus tracking approaches, and diffusion-weighted imaging, including techniques for mapping brain white matter fiber bundles. Clinical applications are reviewed in depth for each technique, with case reports included throughout the book. Attention is also drawn to possible artifacts and pitfalls associated with these techniques.
On the Convergence of Bio-, Information-, Enrivonmental-, Energy-, Space- and Nano-Technolgies
Proceedings of the 1st International Women's Conference on Bien-Technology, Daejeon, Kore, 13-16 November 2003
Calcium-Sensing Receptor
Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline. Calcium-Sensing Receptor is the nineteenth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
