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Gigantism and Acromegaly
Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management...
Adrenal Disease in Childhood
Adrenal disease in children poses an immensely difficult diagnostic and management problem for the paediatrician in view of the large number of rare pathologies that may present in this way. This volume brings together the expertise of the acknowledged leaders in specific adrenal disorders to provide a readily accessible text that combines a detailed description of the molecular origins of these diseases, as they are currently understood, with a unique account of the clinical features and therapeutic options. Beginning with disorders that primarily affect adrenal development and progressing towards the defects that interfere with steroid production, the reader gains considerable insight into the normal physiology of the adrenal cortex particularly as revealed by clinical disorders. The major contributions of modern biochemistry and molecular genetics in our current understanding are visible throughout, providing a unique overview of adrenocortical biology. This book is of great interest to general pediatricians, paediatric endocrinologists, adult endocrinologists, clinical geneticists and basic scientists working in areas such as developmental biology and molecular steroidogenesis.
Genetics of Endocrine Disorders, An Issue of Endocrinology and Metabolism Clinics of North America
This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Constantine A. Stratakis, is devoted to Genetics in Endocrine Disorders. Articles in this issue include: Genetics of Short Stature; Genetics of Diabetes Insipidus; Pituitary Hypoplasia; Pituitary Tumor Genetics and Associated Syndromes; Defects of Thyroid Hormone Synthesis; Molecular Genetics of Thyroid Cancer; Genetics of Hyperparathyroidism Including Parathyroid Cancer; Genetics of Adrenocortical Development and Tumors; Genetics of Congenital Adrenal Hyperplasia; Genetics of Pheochromocytomas and Related Conditions; Genetics of Multiple Endocrine Neoplasia Type 1 and Type 2 Syndromes; Genetics of Hypogonadotrophic Hypogonadism and Kallman Syndrome; Disorders of Sex Development; Genetics of Lipodystrophy; and PTEN-Spectrum Disorders.
Disorders of the Human Adrenal Cortex
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel 'backdoor' pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing's syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
Adrenal Cortex: From Physiology to Disease
The adrenal gland plays essential roles in the control of body homeostasis, stress and immune responses. The adrenal cortex represents up to 90% of the gland and is specialised in the production of mineralocorticoids, glucocorticoids and adrenal androgens. This production is tightly coordinated and results from a unique zonal organisation. Although our knowledge of the molecular mechanisms controlling adrenal steroidogenesis is quite extensive, for decades, the mechanisms of adrenal cortex development, cellular homeostasis and renewal have remained elusive. The advent of new high-throughput technologies and sophisticated genetic approaches has brought tremendous progress in our understanding...
Pediatric Endocrinology
An up-to-date and concise guide to the clinical management of pediatric endocrine disorders. The text covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages.
Encyclopedia of Molecular Mechanisms of Disease
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
Biochemical and Imaging Diagnostics in Endocrinology, An Issue of Endocrinology and Metabolism Clinics of North America
This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Richard Auchus, Adina Turcu, Alan D. Waxman, and Barry D. Pressman, is devoted to Biochemical and Imaging Diagnostics in Endocrinology. Articles in this issue include Mass spectrometry applicability in endocrine testing; Point-of-care endocrine testing; Thyroid, Bone; NET; Predictors of fertility; Thyroid ultrasound imaging and needle biopsy; Pituitary imaging; Adrenal imaging; Pancreatic imaging; Diagnosis and management of thyroid disorders; Neuroendocrine Tumors, and Parathyroid Imaging.
Cardiovascular Outcomes of Treatments available for Patients with Type 1 and 2 Diabetes, An Issue of Endocrinology and Metabolism Clinics of North America, E-Book
This issue of Endocrinology and Metabolism Clinics, edited by Dr. Guillermo E. Umpierrez, will focus on Cardiovascular Outcomes of Treatments available for Patients with Type 1 and 2 Diabetes. Topics include--but are not limited to--Diabetes and CAD and PVD; Prediabetes and CVD- DM prevention; Pathogenesis of atherosclerosis/CVD in diabetes Intensive Diabetes Treatment and CV Outcomes in T1D; Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, Diabetes and Stroke; Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes; Heart Failure in Diabetes Mellitus; Individualizing Glucose Lowering Therapy in the Patient with Diabetes and Heart Disease; Managing Dyslipidemia in Type 2 Diabetes; Blood pressure control and cardiovascular and renal outcomes; Hyperglycemia in acute coronary syndromes; Hospital Glucose Control; Managing Diabetes and cardiovascular risk in chronic kidney disease; and more.
