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The sixth edition of this highly popular text retains its comprehensive coverage of endocrine basics from previous editions while featuring entirely new chapters on several topics, including the assessment of endocrine function, sexual differentiation, growth regulation, the thyroid, the adrenals, and calcium homeostasis. Chapters have been updated and reorganized to make information easily accessible in concise form, and new figures and tables have been added to enhance the presentation of complex concepts. Fundamental principles of endocrine physiology are reinforced with illustrative examples from clinical observation and the limitations of current knowledge are properly identified. The ideal resource for students entering the field, the Textbook of Endocrine Physiology aims to provide for all a solid basis in fundamentals of endocrinology and for some, inspiration for the pursuit of advanced medical or graduate studies in the field.
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel ‘backdoor’ pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing’s syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
This widely used text provides a thoroughly updated account of current knowledge in the endocrine sciences. Each chapter is structured to cover both established concepts and recent developments. The chapters are not only written at a consistent level and well integrated with one another, but they also blend basic science with essential elements of clinical knowledge in order to give students an appreciation of the consequences of deranged endocrine function. The Fifth Edition features completely new versions of the chapters on "Cytokines and Immune-Endocrine Interactions," "The Adrenal Glands," and "Calcium Homeostasis." Many of the illustrations throughout the book are new or have been significantly revised to complement the text. Fresh examples have also been included so that each chapter continues to show clearly the clinical consequences of deranged endocrine function. Much new scientific information has been added on such topics as the nongenomic actions of steroid hormones, relaxin receptors, inhibin B, steroid regulating element-binding proteins, IGF-binding proteins, transcriptional regulation of the developing adipocyte, and the regulation of food intake and body weight.
The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been med...
Thoroughly revised and now enhanced with color artwork, this new edition offers the latest information on the diagnosis and management of reproductive endocrine disorders. As an Expert Consult title, it includes convenient online access to the complete text of the book along with all of the images and references linked to Medline.
Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase, Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase, Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Updated release includes the latest information on Steroid Biochemistry
In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Rachel Pessah-Pollack and Maria Papaleontiou bring their considerable expertise to the topic of Update on Endocrine Disorders During Pregnancy. In recent years, our understanding of endocrine disorders during pregnancy has greatly evolved and changed. In this issue, top experts provide updates on transgender reproductive health, PCOS management during pregnancy, hypertension, diabetes, congenital adrenal hyperplasia during pregnancy, and more. - Contains 13 relevant, practice-oriented topics including hyperthyroidism during pregnancy; pregnancy-related bone loss; challenges of lipid management during pregnancy; Cushing's disease; and more. - Provides in-depth clinical reviews on endocrine disorders during pregnancy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Tarascon Adult Endocrinology Pocketbook is a convenient reference guide that provides a comprehensive review of major endocrine topics along with a succinct presentation of physiology, pathophysiology, and diagnostic and management strategies in endocrinology. Tarascon Adult Endocrinology Pocketbook is a convenient reference guide that provides a comprehensive review of major endocrine topics along with a succinct presentation of physiology, pathophysiology, and diagnostic and management strategies in endocrinology. Endocrine topics include pituitary, thyroid, and adrenal disorders; male and female reproduction; diabetes and obesity; and calcium metabolism and osteoporosis. Tarascon Adult Endocrinology Pocketbook is a must-have tool for practicing primary care physicians as well as medical students, residents and endocrinology fellows.
In this issue of Medical Clinics, guest editors Silvio Inzucchi and Elizabeth Holt bring their considerable expertise to the topic of Endocrinology. - Provides in-depth, clinical reviews in Endocrinology, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mecha...