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Reactive Oxygen Species and Male Fertility
Reactive oxygen species (ROS) are inevitable by-products of aerobic cells. A delicate balance between ROS production and antioxidant defences is essential to assure cell function. This requirement is also true for the spermatozoon, the male gamete, with the unique goal of carrying and delivering the paternal genome into the oocyte. Oxidative stress promotes damage in lipids, proteins and DNA of spermatozoa, and this oxidative damage is associated with infertility. The ROS-dependent damage could occur at different stages of the production and maturation of the sperm. On the other hand, low and controlled levels of ROS are necessary to trigger and regulate sperm function. When ejaculated, sper...
Genetic Damage in Human Spermatozoa
There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
Studies on Men's Health and Fertility
Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling ...
Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family
The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.
Nietzsche and the Gods
"I have slain all gods—for the sake of morality!" — Friedrich Wilhelm Nietzsche Although often regarded as an atheist who did not take religion seriously, Nietzsche in fact thought deeply about the gods and how they functioned in the human psyche. The son of a Lutheran pastor who dropped theology in college after only one semester, Nietzsche was a profound religious thinker who devoted much of his writing to reevaluating the concept of god that prevailed in nineteenth-century Germany. As this volume demonstrates, Nietzsche sharply discerned between the positive and negative aspects of various gods, including the Christian God, the Jewish God (Yahweh), the Greek gods (especially Apollo and Dionysus), and the Buddha. The essays further touch upon Nietzsche's relationship to prominent religious thinkers of his time, as well as his influence on later religious thinkers, such as Martin Buber and Paul Tillich. Wide-ranging and diverse, Nietzsche and the Gods will be indispensable to our continuing understanding of Nietzsche's thought and to the broader study of philosophy and religion.
Program for the Annual Meeting of the Society for the Study of Reproduction
Includes "Abstracts of papers presented at the annual meeting."
Remembering Home in a Time of Mobility
Memory, nostalgia and melancholy have attracted considerable scholarly attention in recent decades. Numerous critics of globalisation, transnationalism and cosmopolitanism have posited an overwhelming feeling of homelessness not only among people who have been displaced from their original home/lands, but also among those who feel estranged from their places of origin due to rapid social change or environmental decline. Arguably, homesickness is prevalent in today’s developed world, and can be – and sometimes indeed is – felt even for times and places unrelated to someone’s personal roots. Memory has been mobilised to justify recent conflicts, to question mainstream interpretations o...
Discourse and the Construction of Society
In this new edition of his seminal theoretical work on myth, ritual, and classification, Bruce Lincoln explores the ways in which these narratives and practices hold human societies together--and how, in times of crisis, they can be used to take a society apart and reconstruct it. The second edition includes three new chapters, new images, and an updated bibliography.
Encyclopedia of Philosophy and the Social Sciences
The entries in this encyclopedia give readers an opportunity to explore interconnections, clarify commonalities as well as differences or comparative contrasts, discover new fields or ideas of intellectual interest, explore adjacent conceptual zones that may be found to further expand their own disciplinary domains, and also understand better their own academic areas of expertise and the historical provenance of each. -- p. xxxi.
