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Schistosomiasis is a major health problem in many tropical areas in the world. This neglected tropical disease is endemic in 78 countries and affects over 250 million worldwide. In 2021 the World Health Organization published the document “Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021−2030”, which established as goals for schistosomiasis (i) elimination of the disease as a public health problem in 78 affected countries by 2030, and (ii) elimination of transmission in 25 endemic countries by 2030. However, to achieve these goals, it is necessary to better understand the disease and its dynamics, the parasite's immunobiolo...
Correlates of Protection (CoP) are biological parameters present in vaccinated or naturally infected individuals that predict levels of protection against an infectious disease. CoP facilitate vaccine licensing since they enable: a) the selection of antigen composition of a vaccine; b) the assessment of vaccine efficacy in clinical trials without exposure of participants to natural infection; and c) bridging between first- and second-generation vaccines.
Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the yea...
Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited sid...
A obra teve por fundamentação o fato inédito de famílias cristalenses: Moreira Maia e Ferreira dos Reis se originarem de dois padres. A história é tecida ao longo de três séculos:final do século XIX, século XX e início do século XXI.
This book includes a selection of the articles accepted for presentation and discussion at the second International Symposium on Qualitative Research (ISQR2017), held in Salamanca, Spain, July 12-14, 2017. ISQR2017 is part of the Iberian-American Congress on Qualitative Research (CIAIQ), and featured four main application fields (Education, Health, Social Sciences, and Engineering and Technology) and seven main subjects: Rationale and Paradigms of Qualitative Research; Systematization of approaches with Qualitative Studies; Qualitative and Mixed Methods Research; Data Analysis Types; Innovative Processes of Qualitative Data Analysis; Qualitative Research in Web Contexts; Qualitative Analysis with the Support of Specific Software. This book is a valuable resource for academics, researchers, teachers and students who need information on the above topics, as well as on the use of Computer Assisted Qualitative Data AnalysiS (CAQDAS).