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A rookie detective investigates the murder of a bestselling mystery writer. Two shots on a snowy Seattle street, and a bestselling writer lies dead. When Brick Ransom is assigned to the case, the trail quickly leads to an up-and-coming hard-boiled mystery writer, his publisher, and one of Seattle's most powerful companies. But who did it? And why? And with the murders still happening, who will be next? Bloody Pulp is bloody good fun, with all of the mystery, suspense, humor, and over-the-top action Brick Ransom fans crave!
A hostage standoff, a weaponized vaccine, and a frantic race to save lives. Software billionaire Jeff Pepper chose the wrong day to check on the research project he's been funding at a Seattle university. When gunmen seize control of the building, aiming to get their hands on a horrifying new weapon, the world-famous entrepreneur is ensnared in a nerve-wracking hostage situation, one in which he is an all-too-valuable pawn. As the body count rises, Pepper's fate rests in the hands of Brick Ransom, a SWAT team leader with a wry sense of humor and a slippery trigger finger. Time is running out, and if Brick and his team can't save him,Pepper will need to use every negotiating trick up his sleeve to see that he and his fellow captives make it out alive...
NMR spectroscopy has found a wide range of applications in life sciences over recent decades. Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies. The major focus is on novel approaches in NMR which deal with the functional interface of either protein-protein interactions or protein-lipid interactions. Bridging the gaps between structural and functional studies, the Editors believe a thorough compilation of these studies will open an entirely new dimension of understanding of crucial functional motifs. This in turn will be helpful for future applications into drug design or better understanding of systems. The book will appeal to NMR practitioners in industry and academia who are looking for a comprehensive understanding of the possibilities of applying high-resolution NMR spectroscopic techniques in probing biomolecular interactions.
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
This book provides a complete overview of current techniques to identify ligands, characterize their binding sites, and understand binding mechanisms. Suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry.
Marsupials are excellent objects for studies on developmental processes in all mammals including humans. Marsupials are very immature at birth and undergo most of their development in a pouch where they can be manipulated in a variety of ways without affecting the mother. Most of these studies are on systems which largely mature before birth in eutherian mammals and are consequently difficult to investigate. Attention is also drawn to certain features peculiar to adult marsupials: e.g., they continue to grow throughout adult life, valuable for studies on growth mechanisms, and furthermore the composition of marsupial milk changes radically through lactation, most important in studies of hormonal regulation of milk composition and secretion.
Form and function in modern biology.
Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods. The text's three sections highlight its ...
Lippincott's Illustrated Reviews: Immunology offers a highly visual presentation of essential immunology material, with all the popular features of the series: more than 300 full-color annotated illustrations, an outline format, chapter summaries, review questions, and case studies that link basic science to real-life clinical situations. Lippincott's Illustrated Reviews: Immunology can be used as a review text for a short immunology course, or paired with Lippincott's Illustrated Reviews: Microbiology for a combined microbiology/immunology course.