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Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-co...
This volume constitutes the refereed proceedings of the Third IFIP WG 5.4. Working Conference on Computer Aided Innovation, CAI 2009, held in Harbin, China, in August 2009. The papers deal with advanced approaches in education and training; data mining; text mining; semantic Web; optimization and innovation, shape and topology generators; design automation; integration of CAI methods and tools into engineering; innovation process and engineering information pipeline; innovation in collaborative networks of enterprises; professional virtual communities as well as engineering design.
Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
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A reinterpretation of world politics drawing on Chinese cultural and philosophical traditions to argue for a focus on relations amongst actors, rather than on the actors individually.