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DNA Vaccines
The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications....
Animal Models in Eye Research
The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. - Presents information on the major animal models used in eye research including invertebrates and vertebrates - Provides researchers with information needed to choose between model organisms - Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery
Rice Boy
When Tina's cousin Tommy arrives on a visit from Canada, the two form a bond and open each other's eyes to a wider world--with life-changing consequences. Penetrating to the heart of the immigrant experience, this award-winning drama explores universal themes of love, loss, and the nature of identity.
Viruses and Human Disease
Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss' virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses a...
Widowhood in an American City
Widowhood in an American City focuses on the roles and lifestyles of urban American widows fifty years of age or older. These women form a segment of two generations of one society; they present a historical instance of people born and brought up under conditions that are not likely to be duplicated. Not only the U.S., but many other countries are undergoing modifications in the degrees and forms of urbanization, industrialization, and social complexity.Helena Znaniecki Lopata argues that the way women re-engage society following the death of a husband is different due to their location in the modern social system. She notes that the trends in social structure are toward increasingly volunta...
Zastrozzi
Zastrozzi, the master criminal of Europe, seeks to kill Verezzi, the saintly artist, for a murder he committed years ago and has blotted from his memory. The aristocratic Zastrozzi wants to destroy culture and morality itself as well as the new middle class and its ideas of enlightenment as well as its mediocrity.
