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In Indian context.
This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors and is relevant for postgraduates, researchers and practitioners.
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
This book focuses on neotectonic movements and river channel evolution of the Indian subcontinent, with special reference to the Himalayan Neotectonics. Neotectonic movements have played an important role in channel evolution in tectonically active zones especially for the mountain chains, foredeeps and active deltas. The book addresses the issues of the channel evolution in neotectonically active domains of India. It aims at readers of India as well as abroad, interested in earth sciences, geomorphology, tectonics, physical geography and river forms and processes of India.
This book gathers selected research articles from the International Conference on Innovative Product Design and Intelligent Manufacturing System (ICIPDIMS 2019), held at the National Institute of Technology, Rourkela, India. The book discusses latest methods and advanced tools from different areas of design and manufacturing technology. The main topics covered include design methodologies, industry 4.0, smart manufacturing, and advances in robotics among others. The contents of this book are useful for academics as well as professionals working in industrial design, mechatronics, robotics, and automation.
Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-...
Climate change is broadly recognized as a key environmental issue affecting social and ecological systems worldwide. At the Cancun summit of the United Nations Framework Convention on Climate Change’s 16th Conference, the parties jointly agreed that the vulnerable groups particularly in developing countries and whose livelihood is based on land use practices are the most common victims as in most cases their activities are shaped by the climate. Therefore, solving the climate dilemma through mitigation processes and scientific research is an ethical concern. Thus combining the knowledge systems of the societies and scientific evidences can greatly assist in the creation of coping mechanisms for sustainable development in a situation of changing climate. International Humboldt Kolleg focusing on “knowledge systems of societies and Climate Change” was organized at ISEC. This event was of unique importance, as the year 2011-12 was celebrated as the 60th Anniversary of Diplomatic Relations between India and Germany with the motto "Germany and India - Infinite Opportunities." This volume is the outcome of the papers presented during the IHK 2011 at ISEC, India.
In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.