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Treatise on Geochemistry
This extensively updated new edition of the widely acclaimed Treatise on Geochemistry has increased its coverage beyond the wide range of geochemical subject areas in the first edition, with five new volumes which include: the history of the atmosphere, geochemistry of mineral deposits, archaeology and anthropology, organic geochemistry and analytical geochemistry. In addition, the original Volume 1 on "Meteorites, Comets, and Planets" was expanded into two separate volumes dealing with meteorites and planets, respectively. These additions increased the number of volumes in the Treatise from 9 to 15 with the index/appendices volume remaining as the last volume (Volume 16). Each of the origin...
Pharmacology of Central Synapses
Pharmacology of Central Synapses deals with the pharmacology of the central nervous system and the mode of action of neurotropic drugs based on their influence on synaptic transmission. The neuronal structure of the nervous system, the structure of the synapses, and the phenomena of electrochemical transmission are discussed in this context. The main propositions of the synaptic theory of the action of neurotropic drugs, based on morphological, physiological, and biochemical findings, form the conceptual basis of this book. Comprised of eight chapters, this book examines the effect of neurotropic drugs on the synaptic transmission in reflex, projection, and association (commissural) tracts. ...
Histamine and Anti-Histaminics
It was an agreable, though strenuous task to edit a book with so many distin guished contributors, on a subject to which I have given half of my life. In 1959, when Prof. O. EICHLER invited me to edit a book on "Histamine and Anti histaminics", as a supplement to HEFFTER'S Handbuch, I thought the task could be done in three years. Now, five years are gone and only half is fulfilled. Though, so far as the "Histamine" part of the book is concerned, the initial plan has been followed very closely, we had to leave the Anti-histaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on M utterkorn, by ARTHUR R. CUSHING were considered enough, in vol. II,...
Drug Discovery and Evaluation
This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
Diamond: Genesis, Mineralogy and Geochemistry
Diamond is the record-setter in many mineralogical properties such as hardness, diffusivity, thermal conductivity, purity, and covalency of bonding. Similarly, diamond, as the premier gemstone of the mantle holds primacy for geological features such as age and depth of origin. Diamond was among the first crystalline structures to be solved by X-ray diffraction and the first materials measured for their Raman spectrum. At more than 80 billion USD in yearly commercial value, diamond sets the record for the most traded, valuable mineral on the planet. Despite its chemical simplicity, diamond has been the object of more research effort, and had more scientific and popular press pages written about it, than any other mineral.
Metabolic Inhibitors V1
Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; th...
Drug Discovery and Evaluation: Pharmacological Assays
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
