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Pediatric Pharmacotherapy
This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
Stochastic Optimization Methods in Finance and Energy
This volume presents a collection of contributions dedicated to applied problems in the financial and energy sectors that have been formulated and solved in a stochastic optimization framework. The invited authors represent a group of scientists and practitioners, who cooperated in recent years to facilitate the growing penetration of stochastic programming techniques in real-world applications, inducing a significant advance over a large spectrum of complex decision problems. After the recent widespread liberalization of the energy sector in Europe and the unprecedented growth of energy prices in international commodity markets, we have witnessed a significant convergence of strategic decis...
Cardiac Catheterization for Congenital Heart Disease
The second edition of this handbook is an up-to-date guide to the application of catheter-based interventions across the entire age range of congenital heart disease patients, from fetal life through to adulthood. It considers the changes and improvements that have occurred during the last few years in terms of new procedures, new tools and devices (in particular in the field of valves), new imaging and pre-procedural strategies, such as 3D-printing, 3D- rotational angiography and fusion imaging. It provides readers with clear instructions on techniques for vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation and on...
Portfolio Risk Analysis
Portfolio risk forecasting has been and continues to be an active research field for both academics and practitioners. Almost all institutional investment management firms use quantitative models for their portfolio forecasting, and researchers have explored models' econometric foundations, relative performance, and implications for capital market behavior and asset pricing equilibrium. Portfolio Risk Analysis provides an insightful and thorough overview of financial risk modeling, with an emphasis on practical applications, empirical reality, and historical perspective. Beginning with mean-variance analysis and the capital asset pricing model, the authors give a comprehensive and detailed a...
Evidence-Based Management of Complex Knee Injuries E-Book
The ultimate resource for sports medicine conditions involving the knee, Evidence-Based Management of Complex Knee Injuries is an up-to-date reference that provides practical tools to examine, understand, and comprehensively treat sports medicine conditions in this challenging area. Using a sound logic of anatomy, biomechanics, lab testing, human testing, and outcomes analysis, editors Robert F. LaPrade and Jorge Chahla offer a single, comprehensive resource for evidence-based guidance on knee pathology. This unique title compiles the knowledge and expertise of world-renowned surgeons and is ideal for sports medicine surgeons, primary care physicians, and anyone who manages and treats patien...
Survival Strategies in Extreme Cold and Desiccation
This book comprehensively describes biological phenomena, adaptation mechanisms, and strategies of living organisms to survive under extremely cold or desiccated conditions at molecular, cellular, and organ levels. It also provides tremendous potential for applications of the findings to a wide variety of industries. The volume consists of three parts: Part 1, Adaptation Mechanisms of Cold, and Part 2, Adaptation Mechanisms of Desiccation, collect up-to-date research on mechanisms and strategies of living organisms such as sleeping chironomids, polar marine fishes, hibernating mammals, bryophytes, dormant seeds, and boreal plants to survive under extreme cold and desiccated conditions at mol...
The Immunological Basis of Asthma
This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and aller
Handbook of Atopic Eczema
State-of-the-art review on atopic eczema, one of the most common skin diseases today. This multi-authored handbook covers all aspects relevant for physicians from various disciplines.
