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Homing Endonucleases and Inteins
This book provides the first and only comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies, which are tied together through their frequent fusion and coevolution, have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.
The Bacteriophages
It has been 10 years since Plenum included a series of reviews on bacte riophages, in Comprehensive Virology. Chapters in that series contained physical-genetic maps but very little DNA sequence information. Now the complete DNA sequence is known for some phages, and the se quences for others will soon follow. During the past 10 years two phages have come into common use as reagents: A phage for cloning single copies of genes, and Ml3 for cloning and DNA sequencing by the dideoxy termi nation method. Also during that period the use of alternative sigma fac tors by RNA polymerase has become established for SPOl and T4. This seems to be a widely used mechanism in bacteria, since it has been im...
Enzybiotics
Presents the latest research and applications for a new, promising approach to fighting infectious diseases Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications. The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores: A new approach to controlling infections using Gram-negative bacteria Bacteriophage holins and their m...
The Bacteriophages
This authoritative, timely, and comprehensively referenced compendium on the bacteriophages explores current views of how viruses infect bacteria. In combination with classical phage molecular genetics, new structural, genomic, and single-molecule technologies have rendered an explosion in our knowledge of phages. Bacteriophages, the most abundant and genetically diverse type of organism in the biosphere, were discovered at the beginning of the 20th century and enjoyed decades of used as anti-bacterial agents before being eclipsed by the antibiotic era. Since 1988, phages have come back into the spotlight as major factors in pathogenesis, bacterial evolution, and ecology. This book reveals their compelling elegence of function and their almost inconceivable diversity. Much of the founding work in molecular biology and structural biology was done on bacteriophages. These are widely used in molecular biology research and in biotechnology, as probes and markers, and in the popular method of assesing gene expression.
Protein-Nucleic Acid Interactions
This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.
Genes And Genomes
The celebrated authors present an in-depth overview of the molecular structures and mechanisms that underlie the utilization of genetic information by complex organisms. They emphasize the experimental aspects of molecular genetics, offering a complete introduction to both principles and methods. "Excellent, suitably detailed and superbly written." Philip Leder, Harvard Medical School
Old Dragon Bestiário
Bem-vindo ao Bestiário do Old Dragon, um livro com presas e garras. Aqui você vai encontra mais de 200 criaturas totalmente detalhadas, com descrições, comportamento, ecologia e estatísticas de jogo dispostas de forma organizada, didática e precisa. Um compêndio completo de ameaças para você tornar seus combates de Old Dragon cada vez mais heroicos, fantásticos e empolgantes. Neste Livro você encontrará: - Mais de 200 monstros com blocos de estatísticas e descricões, completas - Sugestões e dicas para criar seus próprios monstros; - Modelos, uma nova forma de transformar criaturas antigas em novos desafios; - Listas completas para consulta rápida com monstros por Dado de Vida, Habitat e Conceito; - Tabelas de encontros prontas para todos os níveis de personagem; - Nova tabela de Afastar Mortos-Vivos; - Ficha especial para suas novas criações monstruosas Autor: Fabiano Neme Idioma: Português Número de páginas: 224 ISBN: 978-85-65146-06-7 Dimensões: 21×14 cm (A5)
Necronomicon
Kabala'nın yaratılmasından çok önce tapınılan ve çağrılan eski çağlara ait güçler vardır. Bunlar Sümer inancındaki kadimlerdir ve Aleister Crowley'in majisinde ve H.P. Lovecraft'ın mitosunda yaşarlar. Dünyayı bir kez daha yönetmek için kapının hemen ardında beklemektedirler...
