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Physics against cancer
Cancer Treatment, Radiation Oncology, PSI, Pencil Beam Scanning, History of Medicine Modern proton therapy is saving the lives of more and more children and adults with difficult-to-treat cancers. The spectacular rise of proton therapy might never have happened if it were not for the pioneering work of the Paul Scherrer Institute – a Swiss centre founded to explore physics and the nature of matter, but which turned its understanding of basic science into applications that would benefit mankind. This is the place that pioneered a technique of delivering protons to tumours called pencil beam scanning (also known as spot scanning) – now used in nearly every proton therapy centre in the worl...
Shape And Texture Analysis Of Skull-Base Chordomas To Predict The Outcome Of Pencil Beam Scanning Proton Therapy
Purpose: Skull-base chordomas (sbC) are rare bone tumors presenting within the clivus or spinal axis, characterized by significant tissue heterogeneity. Their shapes are variable, likely determined by proximity to surrounding anatomic barriers, making them a typical indication for proton therapy (PT). Here we investigate whether shape and/or textural features of the pre-treatment tumour correlate with clinical outcome.Methods: We retrospectively analyzed 50 sbC patients treated using PBS-PT at our institute. Pre-PT tumor shape and texture (Tab.1) were evaluated on DWI- and T2w-MRI images using in-house developed software and were classified using clustering algorithms (Kmeans) considering bo...
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