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Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
The Olive Principle
Do you remember what it felt like when you first fell in love with Jesus? And then one day, the presence you felt was suddenly gone. Who would willingly allow this to happen? Is there an unseen force that deceives believers? In The Olive Principle, minister and author Daniel R. Dorey discusses the reasons believers are lured away from God and recommends action steps to accepting the challenge of becoming a true servant of God. Complementing the study of scripture, The Olive Principle unravels the twisted deception used by Satan. Dorey brings you face-to-face with the truth and assists you on the path to spiritual maturity, discussing the following topics: The first step in finding your way back to God The hidden principle the olive holds for your life The cure for the I Factor or self-first phenomena The steps to change your relationship with God forever The attitude to bring you into a place of physical and spiritual fulfillment When you understand the true meaning of being a servant, fulfillment is realized in God. There is an attitude that must be grasped for you remain in His presence. Are you ready?
Evolution of NK-mediated target recognition under the pressure of physiologic or pathologic stimuli
Since their discovery NK cells have come out as potential tools to fight cancer and viruses. This finding early urged different groups to study the mechanisms governing NK cell function. The identification of the MHC-I-specific inhibitory receptors (i.e. KIRs, NKG2A and certain Ly49 molecules) allowed defining rather rapidly how NK cells could avoid self-aggression and how they could be directed towards targets that were forced, by viral infection or tumor transformation, to down-regulate MHC-I expression. In a second time, also the repertoire of surface activating receptors addressing NK cytotoxicity towards tumors and pathogens was mostly defined. In spite of the first findings, however, m...
Daniel Webster and the Oratory of Civil Religion
Annotation Daniel Webster (1782-1852) embodied the golden age of oratory in America by mastering each of the major genres of public speaking of the time. Even today, many of his victories before the Supreme Court remain as precedents. Webster served in the House, the Senate, and twice as secretary of state. He was so famous as a political orator that his reply "Liberty and Union, now and forever, one and inseparable!" to Senator Robert Hayne in a debate in 1830 was memorized by schoolboys and was on the lips of Northern soldiers as they charged forward in the Civil War. There would have been no 1850 Compromise without Webster, and without the Compromise, the Civil War might well have come ea...
