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This textbook for a second course in basic statistics for undergraduates or first-year graduate students introduces linear regression models and describes other linear models including Poisson regression, logistic regression, proportional hazards regression, and nonparametric regression. Numerous examples drawn from the news and current events with an emphasis on health issues illustrate these concepts. Assuming only a pre-calculus background, the author keeps equations to a minimum and demonstrates all computations using SAS. Most of the programs and output are displayed in a self-contained way, with an emphasis on the interpretation of the output in terms of how it relates to the motivating example. Plenty of exercises conclude every chapter. All of the datasets and SAS programs are available from the book's website, along with other ancillary material.
Discrete or count data arise in experiments where the outcome variables are the numbers of individuals classified into unique, non-overlapping categories. This revised edition describes the statistical models used in the analysis and summary of such data, and provides a sound introduction to the subject for graduate students and practitioners needing a review of the methodology. With many numerical examples throughout, it includes topics not covered in depth elsewhere, such as thenegative multinomial distribution; the many forms of the hypergeometric distribution; and coordinate free models. A detailed treatment of sample size estimation and power are given in terms of both exact inference a...
This book brings the power of multivariate statistics to graduate-level practitioners, making these analytical methods accessible without lengthy mathematical derivations. Using the open source, shareware program R, Professor Zelterman demonstrates the process and outcomes for a wide array of multivariate statistical applications. Chapters cover graphical displays, linear algebra, univariate, bivariate and multivariate normal distributions, factor methods, linear regression, discrimination and classification, clustering, time series models, and additional methods. Zelterman uses practical examples from diverse disciplines to welcome readers from a variety of academic specialties. Those with ...
Revised edition of: Applied linear models with SAS, 2010.
Now in its second edition, this book brings multivariate statistics to graduate-level practitioners, making these analytical methods accessible without lengthy mathematical derivations. Using the open source shareware program R, Dr. Zelterman demonstrates the process and outcomes for a wide array of multivariate statistical applications. Chapters cover graphical displays; linear algebra; univariate, bivariate and multivariate normal distributions; factor methods; linear regression; discrimination and classification; clustering; time series models; and additional methods. He uses practical examples from diverse disciplines, to welcome readers from a variety of academic specialties. Each chapter includes exercises, real data sets, and R implementations. The book avoids theoretical derivations beyond those needed to fully appreciate the methods. Prior experience with R is not necessary. New to this edition are chapters devoted to longitudinal studies and the clustering of large data. It is an excellent resource for students of multivariate statistics, as well as practitioners in the health and life sciences who are looking to integrate statistics into their work.
A collection of refereed papers from a six-week workshop on statistics in the health sciences, that brought together theoretical and applied statisticians from universities, medical and public health schools, government and private research institutions, and pharmaceutical companies involved in prediction problems in the life and social sciences and in diagnostic and screening tests. A number of papers with applications were presented and particularly lively discussions ensued involving the critical issues and difficulties in using and interpreting diagnostic tests and implementing mass screening programs. The prediction or controlling future events, such as survival, comparative survival and survival post intervention for a disease or even for certain biological or natural events was also represented by participants who presented work that devised predictive methodology for a variety of problems mainly from a Bayesian perspective.
Easy-to-read and comprehensive, this book shows how the SAS System performs multivariate time series analysis and features the advanced SAS procedures STATSPACE, ARIMA, and SPECTRA. The interrelationship of SAS/ETS procedures is demonstrated with an accompanying discussion of how the choice of a procedure depends on the data to be analysed and the reults desired. Other topics covered include detecting sinusoidal components in time series models and performing bivariate corr-spectral analysis and comparing the results with the standard transfer function methodology. The authors? unique approach to integrating students in a variety of disciplines and industries. Emphasis is on correct interpretation of output to draw meaningful conclusions. The volume, co-pubished by SAS and JWS, features both theory and practicality, and accompanies a soon-to-be extensive library of SAS hands-on manuals in a multitude of statistical areas. The book can be used with a number of hardware-specific computing machines including CMS, Mac, MVS, Opem VMS Alpha, Opmen VMS VAX, OS/390, OS/2, UNIX, and Windows.
Introduces a range of data analysis problems encountered in drug development and illustrates them using case studies from actual pre-clinical experiments and clinical studies. Includes a discussion of methodological issues, practical advice from subject matter experts, and review of relevant regulatory guidelines.
This indispensable guide focuses on validating programs written to support the clinical trial process from after the data collection stage to generating reports and submitting data and output to the Food and Drug Administration.
Written in an easy-to-use, logical format, this comprehensive reference focuses on the functionality of the procedure as well as the accomplishment of common tasks using PROC SQL, enabling readers to quickly develop and enhance their SQL skills. Features include more than 300 examples of PROC SQL code, plus queries and diagrams.