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Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phe...
This textbook, now in its fourth edition, offers a rigorous and self-contained introduction to the theory of continuous-time stochastic processes, stochastic integrals, and stochastic differential equations. Expertly balancing theory and applications, it features concrete examples of modeling real-world problems from biology, medicine, finance, and insurance using stochastic methods. No previous knowledge of stochastic processes is required. Unlike other books on stochastic methods that specialize in a specific field of applications, this volume examines the ways in which similar stochastic methods can be applied across different fields. Beginning with the fundamentals of probability, the au...
This book collects contributions presented at the INdAM Workshop "Mathematical modeling and Analysis of degradation and restoration in Cultural Heritage–MACH2021", held in Rome, Italy in September 2021. The book is focused on mathematical modeling and simulation techniques with the aim of improving the current strategies of conservation and restoration in cultural heritage, sharing different experiences and approaches. The main topics are corrosion and sulphation of materials, damage and fractures, stress in thermomechanical systems, contact and adhesion problems, and phase transitions.
Polymers are substances made of macromolecules formed by thousands of atoms organized in one (homopolymers) or more (copolymers) groups that repeat themselves to form linear or branched chains, or lattice structures. The concept of polymer traces back to the years 1920's and is one of the most significant ideas of last century. It has given great impulse to indus try but also to fundamental research, including life sciences. Macromolecules are made of sm all molecules known as monomers. The process that brings monomers into polymers is known as polymerization. A fundamental contri bution to the industrial production of polymers, particularly polypropylene and polyethylene, is due to the Nobe...
Standing at the intersection of mathematics and scientific computing, this collection of state-of-the-art papers in nonlinear PDEs examines their applications to subjects as diverse as dynamical systems, computational mechanics, and the mathematics of finance.
The aim of this volume that presents lectures given at a joint CIME and Banach Center Summer School, is to offer a broad presentation of a class of updated methods providing a mathematical framework for the development of a hierarchy of models of complex systems in the natural sciences, with a special attention to biology and medicine. Mastering complexity implies sharing different tools requiring much higher level of communication between different mathematical and scientific schools, for solving classes of problems of the same nature. Today more than ever, one of the most important challenges derives from the need to bridge parts of a system evolving at different time and space scales, especially with respect to computational affordability. As a result the content has a rather general character; the main role is played by stochastic processes, positive semigroups, asymptotic analysis, kinetic theory, continuum theory, and game theory.
- Only book on extensive, deterministic models, statistic models, stochastic models and state space models and statistical methods for HIV epidemic involving IV drug usage and HIV epidemic in homosexual populations. - Provides most recent biological insights into HIV pathogenesis and HIV kinetics at the cellular level, and illustrates how to build up mathematical models based on these biological insights. - Only publication that provides in-depth analysis of HAART treatment protocols and discusses possible improvements to the HAART protocol. The book also provides connection between pharmacokinetics with treatment in HIV-infected individuals.
This book consists of lecture notes of a summer school named after the late Jacques Louis Lions. The summer school was designed to alert both Academia and Industry to the increasing role of multidisciplinary methods and tools for the design of complex products in various areas of socio-economic interest. This volume offers the reader a rare opportunity of being exposed to the presentation of real industrial and societal problems together with the relevant innovative methods used.
This book constitutes the thoroughly refereed postproceedings of the 14th Italian Workshop on Neural Networks, WIRN VIETRI 2003, held in Vietri sul Mare, Italy in June 2003. The 41 revised papers presented were carefully reviewed and improved during two rounds of selection and refereeing. The papers are organized in topical sections on models for neural computation; architectures and algorithms; image and signal processing; applications; bioinformatics and statistics; and formats of knowledge: words, images, and narratives.
The summer school on Mathematics inspired by Biology was held at Martina Franca, Apulia, Italy in 1997. This volume presents five series of six lectures each. The common theme is the role of structure in shaping transient and ultimate dynamics. But the type of structure ranges from spatial (hadeler and maini in the deterministic setting, Durrett in the stochastic setting) to physiological (Diekmann) and order (Smith). Each contribution sketches the present state of affairs while, by including some wishful thinking, pointing at open problems that deserve attention.