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Teaching a Dark Chapter
Teaching a Dark Chapter explores how textbook narratives about the Fascist/Nazi past in Italy, East Germany, and West Germany followed relatively calm, undisturbed paths of little change until isolated "flashpoints" catalyzed the educational infrastructure into periods of rapid transformation. Though these flashpoints varied among Italy and the Germanys, they all roughly conformed to a chronological scheme and permanently changed how each "dark past" was represented. Historians have often neglected textbooks as sources in their engagement with the reconstruction of postfascist states and the development of postwar memory culture. But as Teaching a Dark Chapter demonstrates, textbooks yield n...
Unter alliierter Besatzung
Mit der Invasion Siziliens durch britische und US-Einheiten im Juli 1943 begann auch die Militärverwaltung durch die Alliierten in Italien. Der Zusammenbruch des faschistischen Regimes, der Waffenstillstand zwischen den Alliierten und Italien und der italienische Frontenwechsel änderten deren Bedingungen und Kontexte massiv. Ohnehin verlor die weitreichende Vorbereitung auf die Besatzung bei der Konfrontation mit süditalienischen Dorfstrukturen und Stadtgesellschaften rasch an Wert. An diesem Punkt setzt die Studie ein, die mit einem praxistheoretisch informierten transnationalen Ansatz einen Beitrag zur Geschichte des Zweiten Weltkriegs im Mittelmeerraum leistet. Sie untersucht die zahlr...
Neurodegenerative Diseases
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Pharmacophores and Pharmacophore Searches
This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.
MGH Cardiology Board Review
This comprehensively revised new edition prepares the reader for the cardiology board examination, as well as provide a concise review of the essentials of general cardiology and the less common but clinically relevant topics in a dynamic and time-efficient manner, augmenting existing learning. It uses board-style questions and answers at the end of each topic, enabling readers to test their learning and commit key concepts to long-term memory. Instructive figures and tables are used to consolidate teaching points. This book also contains practical tips from recent board exam takers and other resources in order to make best use of the reader’s limited time. In the MGH Cardiology Board Revi...
The Physics of Cancer
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
The Dementias
The only guide to focus primarily on current molecular methods of diagnosis and early stage evaluation, this reference presents the latest techniques and technologies for dementia identification and evaluation, including neuropathological strategies, neuropsychological tests, biomarkers, CT, MRI, functional MRI, PET, and SPECT. Offering practical care and examination guidelines, each chapter provides findings that are particularly relevant for the assessment of disorders such as Alzheimer's disease, dementia with Lewy bodies, vascular dementia, and fronto-temporal dementia.
