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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Footnotes
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Annual Report
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Proceedings of the Section on Survey Research Methods
Papers presented at the annual meeting of the American Statistical Association.
The Shrine
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Dun's Consultants Directory
Includes information about the twenty-five thousand largest consulting firms in the U.S. Consultants are listed alphabetically and indexed by geography and consulting activities.
Pharmacokinetics in Drug Development
These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.
Warbirds of America, Inc: 1989
This organization helps to preserve, own, and fly military aircraft from World War II and the Korean War.
