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Model Neural Networks and Behavior
The most conspicuous function of the nervous system is to control animal behav ior. From the complex operations of learning and mentation to the molecular con figuration of ionic channels, the nervous system serves as the interface between an animal and its environment. To study and understand the fundamental mecha nisms underlying the control of behavior, it is often both necessary and desirable to employ biological systems with characteristics especially suitable for answering specific questions. In neurobiology, many invertebrates have become established as model systems for investigations at both the systems and the cellular level. Large, readily identifiable neurons have made invertebrates especially useful for cellular studies. The fact that these neurons occur in much smaller numbers than those in higher animals also makes them important for circuit analysis. Although important differences exist, some of the questions that would be tech nically impossible to answer with vertebrates can become experimentally tractable with invertebrates.
Neuronal Development
Studies of simple and emerging systems have been undertaken to un derstand the processes by which a developing system unfolds, and to understand more completely the basis of the complexity of the fully formed structures. The nervous system has long been particularly in triguing for such studies, because of the early recognition of a multitude of distinctly differentiated states exhibited by nerve cells with different morphologies. Anatomical studies suggest that one liver cell may be very like another, but indicate that neurons come in a remarkable di versity of forms. This diversity at the anatomical level has parallels at the physiological and biochemical levels. It is becoming increasingl...
Physiology Or Medicine
During the period 1981 ? 1990, important areas of research being recognized were visual information processing, monoclonal antibodies, pharmacology, molecular biology and transplantation. The laureates according to the specific year are: (1981) R W SPERRY ? for his discoveries concerning the functional specialization of the cerebral hemispheres; D H HUBEL & T N WIESEL ? for their discoveries concerning information processing in the visual system; (1982) S K BERGSTRM, B I SAMUELSSON & J R VANE ? for their discoveries concerning prostaglandins and related biologically active substances; (1983) B McCLINTOCK ? for her discovery of mobile genetic elements; (1984) N K JERNE, G J F KHLER & C MI...
Cell Lineage and Fate Determination
Cell Lineage and Fate Determination provides a comprehensive view of the mechanisms regulating cell lineage and fate determination in an effort to understand how the fertilized egg is transformed into a complex of specialized tissues. It presents basic information on eight different animal models and recent developmental biological research done in each model. The book provides a focused forum presenting key information for researchers studying various aspects of developmental and cellular biology. Extensive use of tables and black-and-white and color figures helps illustrate each model. The book concludes by discussing future goals for bringing cellular, molecular, and genetic research to clinical applications and tissue replacement therapies.Key Features* Presents eight different animal models* Provides a focused forum on cell fate determination that provides comprehensive and key information for researchers* Illustrates the transitional relationship between researchers and clinicians* Includes the extensive use of tables and color figures
Research Grants
None
The Cellular and Molecular Biology of Pattern Formation
The mechanisms that control region-specific and axial patterning of cell differentiation during embryogenesis have fascinated experimental biologists for over 100 years. This book describes recent advances in our knowledge of the cellular and molecular mechanisms of pattern formation. The contributors, all active experimentalists, describe research within the two main conceptual frameworks currently employed for analyzing patterning: positional information and induction. The developmental time frame covered extends from the oocyte to developing organ systems, and a wide range of research organisms, from hydrozoans to birds is represented.
Asymmetric Cell Division
Cell biologists have recently come to understand that asymmetry of division is an important regulatory phenomenon in the fate of a cell. In adult organisms asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to aging. This book describes the phenomenon in different organisms and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Current Topics in Developmental Biology
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
