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B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, s...
This revealing portrait of the oceanic Dutch Empire exposes the maritime world as a catalyst for the downfall of European imperialism.
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Wheeler Thackstons lively new translation ofThe Jahangirnama, co-published with the Freer/Arthur M. Sackler Gallery of the Smithsonian Institution, presents an engaging portrait of an intriguing emperor and his flourishing empire. The Emperor Jahangir is probably best know in the West as being the father of Shahjahan, who built the Taj Mahal. His reign was one of great prosperity, and his passion for art and nature encouraged a flowering that some say rivaled European art during the rule of the Medicis. In penning his memoirs, Jahangir followed a tradition begun by his great-grandfather, the Emperor Babur. Jahangirs memoirs, however, provide not only the history of his reign, but also his re...
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