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AFTER SUCCESSFUL MILITARY CAREER, SGT. COSGROVE refl ects back on an almost impossible mission he took part in as a young soldier in Korea. During which, he kills. After his wife passed away and his daughter left him, he fi nds himself more and more disinterested in the successful business that he created. His mind keeps drifting back to that snow-covered fi eld on that cold day over 40 years ago. The rush of men yelling, bullets flying, thinking of death, he decides to track down the four men that he saved that day and see how their lives turned out. In doing so, he enters into a complicated and dangerous situation created by the lives of the men and their families and the lives they lived and died.
This book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.
This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.
The introduction of ultrasound has radically altered the clinical approach to patients with digestive diseases as it is now possible to observe the abdominal organs rapidly and noninvasively. This publication thoroughly covers the main applications of ultrasound in gastroenterology, with particular reference to the most recent progress in the field. The articles, contributed by leading international experts, are organized into three sections. The first section of the book focuses on the applications of transabdominal and intraoperative ultrasound in the diagnosis of diseases of the liver and pancreas. A further section deals with interventional ultrasound where the treatment of hepatocellula...
Includes bibliographical references and index.
This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process. With the user rather than the developer of chemoinformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using chemoinformatics tools -- from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition. An invaluable resource for drug developers and medicinal chemists in academia and industry.
For a long time I have felt that the present gynaecological training for registrars lacked familiarisation and understanding of the basic principles of surgery. This is due to several factors. Firstly, the historical separation of gynaecology from general surgery which led to our development as an independent speciality (and which Victor Bonney foretold to our detriment when he opposed the formation of the College of Obstetricians and Gynaecologists as a separate body from the College of Surgeons). Secondly, a vast improvement in medical management of many gynaecological conditions has made surgical practice dull and an unquestioning daily routine with little or no surgical instruction for m...
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