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Old Mansfield Woodhouse
The attractive village of Mansfield Woodhouse was originally rural, but from the nineteenth century many of its inhabitants operated framework knitting machines for a living. Then, in 1903, the opening of Sherwood Colliery saw a great influx of new workers and a consequent building boom to accommodate them. A railway station reached the village in 1875, and trams followed in 1906 allowing the population greater freedom of movement. Pictures in the book include several of the trams and tramway, the Royal Hotel, the Angel Inn, Clerkson's Hall, Mansfield and Sherwood Collieries, the mines rescue station and Woodhouse Castle.
Druggable Lipid Signaling Pathways
Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulato...
River Conservation and Management
This book is intended for those with an academic, scientific and practical interest in river conservation and management. It provides an overview of how changes in legislation, policies, institutional responsibilities, science, technology, practical techniques and public perception have influenced how rivers have been managed over the past 20 years and the challenges that lie ahead during the next 20 years. The book is based on the international conference River Conservation and Management:20 Years On held at York. Thirty-one chapters, with contributions from North and South America, Europe, Asia and Australasia provide a wide-ranging perspective on this complex but profoundly important subj...
Ecology of Industrial Pollution
Written for researchers and practitioners in environmental pollution, management and ecology, this interdisciplinary account explores the ecological issues associated with industrial pollution to provide a complete picture of this important environmental problem from cause to effect to solution. Bringing together diverse viewpoints from academia and environmental agencies and regulators, the contributors cover such topics as biological resources of mining areas, biomonitoring of freshwater and marine ecosystems and risk assessment of contaminated land in order to explore important questions such as: What are the effects of pollutants on functional ecology and ecosystems? Do current monitoring techniques accurately signal the extent of industrial pollution? Does existing policy provide a coherent and practicable approach? Case studies from throughout the world illustrate major themes and provide valuable insights into the positive and negative effects of industrial pollution, the provision of appropriate monitoring schemes and the design of remediation and restoration strategies.
River Conservation and Management
This book is intended for those with an academic, scientific and practical interest in river conservation and management. It provides an overview of how changes in legislation, policies, institutional responsibilities, science, technology, practical techniques and public perception have influenced how rivers have been managed over the past 20 years and the challenges that lie ahead during the next 20 years. The book is based on the international conference River Conservation and Management:20 Years On held at York. Thirty-one chapters, with contributions from North and South America, Europe, Asia and Australasia provide a wide-ranging perspective on this complex but profoundly important subj...
Old Retford
Retford's impressive market square - both on market day and during quieter times - features alongside pictures of the town's fire engine and crew in the late 1940s, youngsters fishing on the River Idle, Trinity Hospital and the Chesterfield Canal. Also included are Strawberry Terrace, one of the town's former windmills, the Picture House on Carolgate, Retford Grammar School and the royal visit of 1914.
Rho Gtpases: Molecular Biology In Health And Disease
Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology.This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also desc...
The City Record
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