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Pharmacokinetic Challenges in Drug Discovery
Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.
Independent Schools Yearbook 2012-2013
The highly-respected book of reference of sought-after Independent Schools in membership of the Independent Schools Council's Associations: HMC, GSA, The Society of Heads, IAPS, ISA and COBIS.
Electronic Visual Music
Electronic Visual Music is a comprehensive guide to the composition and performance of visual music, and an essential text for those wanting to explore the history, current practice, performance strategies, compositional methodologies and practical techniques for conceiving and creating electronic visual music. Beginning with historical perspectives to inspire the reader to work creatively and develop their own individual style, visual music theory is then discussed in an accessible form, providing a series of strategies for implementing ideas. Including interviews with current practitioners, Electronic Visual Music provides insight into contemporary working methods and gives a snapshot of the state of the art in this ever-evolving creative discipline. This book is a valuable resource for artists and practitioners, as well as students, educators and researchers working in disciplines such as music composition, music production, video arts, animation and related media arts, who are interested in informing their own work and learning new strategies and techniques for exploration and creative expression of electronic visual music.
The Baghdad Railway Club
Baghdad 1917. Captain Jim Stringer, invalided from the Western Front, has been dispatched to investigate what looks like a nasty case of treason. He arrives to find a city on the point of insurrection, his cover apparently blown - and his only contact lying dead with flies in his eyes. As Baghdad swelters in a particularly torrid summer, the heat alone threatens the lives of the British soldiers who occupy the city. The recently ejected Turks are still a danger - and many of the local Arabs are none too friendly either. For Jim, who is not particularly good in warm weather, the situation grows pricklier by the day. Aside from his investigation, he is working on the railways around the city. His boss is the charming, enigmatic Lieutenant-Colonel Shepherd, who presides over the gracious dining society called The Baghdad Railway Club - and who may or may not be a Turkish agent. Jim's search for the truth brings him up against murderous violence in a heat-dazed, labyrinthine city where an enemy awaits around every corner.
The Fifteenth Century XII
Described as "a golden age of pathogens", the long fifteenth century was notable for a series of international, national and regional epidemics that had a profound effect upon the fabric of society. The impact of pestilence upon the literary, religious, social and political life of men, women and children throughout Europe and beyond continues to excite lively debate among historians, as the ten papers presented in this volume confirm. They deal with the response of urban communities in England, France and Italy to matters of public health, governance and welfare, as well as addressing the reactions of the medical profession to successive outbreaks of disease, and of individuals to the omnipresence of Death, while two, very different, essays examine the important, if sometimes controversial, contribution now being made by microbiologists to our understanding of the Black Death.
The Gramophone
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