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Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)
Many therapeutic interventions for autism spectrum disorder fail when they are examined in a clinical trial. Frequently, there is a subset of patients that responds very well to the intervention, while others do not, and the overall result does not yield a positive result. As autism spectrum disorder is highly heterogeneous in its underlying genetics and other etiological risk factors, as well as its heterogeneous phenotypic manifestation, this variability in response to any specific treatment is not entirely surprising. However, it remains a challenge to meaningfully subtype this heterogeneity for targeted treatment. The purpose of this research topic is to solicit articles that address the...
The Neuropsychology of Autism
The Neuropsychology of Autism provides an up-to-date summary on the neuropsychology of autism spectrum disorders (ASD), written by leaders in the field. It summarizes current knowledge about neurochemistry, neuroanatomy, genetics, and clinical presentations and provides helpful discussions on key functions such as language, memory, attention, executive functions, social cognition, motor and sensory functioning.
Essential Pathways and Circuits of Autism Pathogenesis
The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity ...
The Creative Brain
A nuanced, science-based understanding of the creative mind that dispels the pervasive myths we hold about the human brain—but also uncovers the truth at their cores. What is the relationship between creativity and madness? Creativity and intelligence? Do psychedelics truly enhance creativity? How should we understand the left and right hemispheres of the brain? Is the left brain, in fact, the seat of reasoning and the right brain the seat of creativity? These are just some of the questions Anna Abraham, a renowned expert of human creativity and the imagination, explores in The Creative Brain, a fascinating deep dive into the origins of the seven most common beliefs about the human brain. ...
Clinical Neurology of Aging
This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, this edition contains subjects ranging from geriatric assessment to pain management and palliative care.
The Roots of Cognitive Neuroscience
The Roots of Cognitive Neuroscience examines the way brain damage can impair our cognitive and emotional systems. In chapters that range from examining memory and language to emotions and creativity, this book demonstrates that behavioral neurology and neuropsychology are just as relevant today as these research strategies were 150 years ago.
The Neurochemical Basis of Autism
A perceived rise in autism worldwide has led to a dramatic increase in autism research. This is a uniquely interdisciplinary text that presents the latest findings regarding the physiological, neuropathological, neurochemical and clinical elements of autism.
Neuroscience of Creativity
Experts describe current perspectives and experimental approaches to understanding the neural bases of creativity. This volume offers a comprehensive overview of the latest neuroscientific approaches to the scientific study of creativity. In chapters that progress logically from neurobiological fundamentals to systems neuroscience and neuroimaging, leading scholars describe the latest theoretical, genetic, structural, clinical, functional, and applied research on the neural bases of creativity. The treatment is both broad and in depth, offering a range of neuroscientific perspectives with detailed coverage by experts in each area. The contributors discuss such issues as the heritability of c...
