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Cell Culture Engineering and Technology
This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
Computational Fluid Dynamics
Computational fluid dynamics (CFD) is a powerful tool that enables engineers and scientists to simulate fluid flows in a variety of applications, including thermal engineering, biomedical engineering, and environmental modeling. This book provides a comprehensive introduction to CFD, encompassing fundamental theory, mathematical and numerical techniques, and practical applications. The book begins by systematically introducing the basic concepts and terminology of CFD, such as the continuity equation, Navier-Stokes equations, energy equation, source/sink terms, and types of grids. The mathematical and numerical methods utilized to solve the CFD governing equations, including the finite diffe...
Biopharmaceutical Manufacturing
This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing prod...
Plant Tissue Culture Engineering
It is my privilege to contribute the foreword for this unique volume entitled: “Plant Tissue Culture Engineering,” edited by S. Dutta Gupta and Y. Ibaraki. While there have been a number of volumes published regarding the basic methods and applications of plant tissue and cell culture technologies, and even considerable attention provided to bioreactor design, relatively little attention has been afforded to the engineering principles that have emerged as critical contributions to the commercial applications of plant biotechnologies. This volume, “Plant Tissue Culture Engineering,” signals a turning point: the recognition that this specialized field of plant science must be integrate...
Computational Fluid Dynamics
This book is planned to publish with an objective to provide a state-of-art reference book in the area of computational fluid dynamics for CFD engineers, scientists, applied physicists and post-graduate students. Also the aim of the book is the continuous and timely dissemination of new and innovative CFD research and developments. This reference book is a collection of 14 chapters characterized in 4 parts: modern principles of CFD, CFD in physics, industrial and in castle. This book provides a comprehensive overview of the computational experiment technology, numerical simulation of the hydrodynamics and heat transfer processes in a two dimensional gas, application of lattice Boltzmann method in heat transfer and fluid flow, etc. Several interesting applications area are also discusses in the book like underwater vehicle propeller, the flow behavior in gas-cooled nuclear reactors, simulation odour dispersion around windbreaks and so on.
Animal Cell Culture
Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both resear...
Production of Biomass and Bioactive Compounds Using Bioreactor Technology
The bioactive compounds of plants have world-wide applications in pharmaceutical, nutraceutical and food industry with a huge market. In this book, a group of active researchers have addressed on the most recent advances in plant cell and organ cultures for the production of biomass and bioactive compounds using bioreactors. Tremendous efforts have been made to commercialize the production of plant metabolites by employing plant cell and organ cultures in bioreactors. This book emphasizes on the fundamental topics like designing of bioreactors for plant cell and organ cultures, various types of bioreactors including stirred tank, airlift, photo-bioreactor, disposable bioreactor used for plan...
Plant Biotechnology and Transgenic Plants
Contains case studies illustrating the cell culture production of pigments, flavors, and antineoplastic compounds Plant Biotechnology and Transgenic Plants covers topics that range from food to fragrances to fuel. It includes discussions of technologies and research on the engineering, synthesis, utilization, and control of primary and secondary pl
Cells and Biomaterials in Regenerative Medicine
This book serves as a good starting point for anyone interested in the application of tissue engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications. The first part covers the use of adult stem cells and their applications. The following chapters offer an insight into the development of a tailored biomaterial for organ replacement and highlight the importance of cell-biomaterial interaction. In summary, this book offers insights into a wide variety of cells, biomaterials, interfaces and applications of the next generation biotechnology, which is tissue engineering.
