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The Victims at the Berlin Wall, 1961-1989
Although many deaths at the Berlin Wall have been publicized over the years in the media, the number, identity and fate of the victims still remain largely unknown. This handbook changes this by answering the following questions: How many people actually died at the Berlin Wall between 1961 and 1989? Who were these people? How did they die? How were their relatives and their friends treated after their deaths? What public and political reactions were triggered in the East and the West by these fatalities? What were the consequences for the border guards who pulled the trigger and the military and political leaders who gave them their orders after the East German border regime collapsed and the Wall fell? How have the victims been commemorated since their deaths? By documenting the lives and circumstances under which these men and women died at the Wall, these deaths are placed in a contemporary historical context. The authors, in addition to systematically researching the relevant archives and examining all the legal proceedings and Stasi documents, also conducted interviews with family members and contemporary witnesses.
Gammadelta T Cells in Cancer Immunotherapy
Gammadelta T cells in Cancer Immunotherapy shows how the potential of ?d T-cells can effectively be translated into clinical benefit in cancer immunotherapies. With a strong focus on finding alternatives to current T cell mediated cancer immunotherapies, the book can also be used as a baseline initial introduction to the field of gamma delta immunotherapy. In 13 chapters Gammadelta T cells in cancer immunotherapy describes different approaches to a specific model of gammadelta immunotherapy including 'delta one T' (DOT) and Allogeneic CAR. It describes the rationale for the use of gamma delta cells in immunotherapy, strategies, therapies, and cancer treatment. Gammadelta T cells in Cancer Im...
Treatment of Autoimmune Disorders
Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.
γδ T cells in Cancer
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). Dr. Dieter Kabelitz currently serves as the chairman for the IUIS Education Committee. Topic Editor Prof. Ilan Bank is Chief Scientific Officer of GammaCell Bio-Technologies Ltd. Topic Editor Prof. Jurgen Kuball is co-founder and scientific advisor of GADETA. Topic Editor Prof. Bruno Silva-Santos is co-founder of Lymphact S.A., a company now owned by GammaDelta Therapeutics. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Immunology of Infection
Immunology of Infection, 3e, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in analyzing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes" and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
The Present and Future of Immunology Education
The explosion of basic and applied immunology in the first decades of the 21st century has brought forth new opportunities and challenges for immunology education at all academic levels, from professional to undergraduate, medical, graduate and post-graduate instruction. Moreover, developing methods and techniques for educating general audiences on the importance and benefits of immunology will be critical for increasing public awareness and support. One major immediate challenge consists in accommodating, within the confines of traditional immunology curricula, a body of knowledge that continues to grow exponentially in both size and complexity. Furthermore, the practical toolbox of immunol...
Tumor Immunology and Immunotherapy - Cellular Methods Part A
Tumor Immunology and Immunotherapy - Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more.
Cellular Diagnostics
This book is the updated English version of the 2006 German bestseller Zellulare Diagnostik, a comprehensive presentation of flow cytometry and its applications. While some techniques of immunophenotyping by flow cytometry already are routine procedures in the laboratory, new methods for the functional characterization of cells, the analysis of rare cells, and the diagnosis of complex materials have only begun to win wide recognition. New approaches such as slide-based cytometry will lead to an increase in the use of cytometric techniques. Multiparameter approaches will further improve analysis. The book provides a comprehensive and detailed compilation of all aspects of flow cytometry in research and the clinic. For newcomers it offers a thorough introduction, for advanced users, specific protocols and interpretation assistance.
