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This book constitutes the refereed proceedings of the International Symposium of Formal Methods Europe, FME 2003, held in Pisa, Italy in September 2003. The 44 revised full papers presented together with 5 invited papers were carefully reviewed and selected from 144 submissions. The papers are organized in topical sections on industrial issues, control systems and applications, communication system verfication, co-specification and compilers, composition, Java, object-orientation and modularity, model checking, parallel processes, program checking and testing, B method, and security.
Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.
The emerging understanding of age-related neurological disorders suggests that notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders probably arise due to a unique intersection of multiple genetic and toxic factors, combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end-state disease, each is a spectrum disorder, and every individual case is therefore unique. Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how they arise and progress...
This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms
This five-volume set clearly manifests the great significance of these key technologies for the new economies of the new millennium. The discussions provide a wealth of practical ideas intended to foster innovation in thought and, consequently, in the further development of technology. Together, they comprise a significant and uniquely comprehensive reference source for research workers, practitioners, computer scientists, academics, students, and others on the international scene for years to come.
This book constitutes the refereed proceedings of the 9th European Workshop on Software Process Technology, EWSPT 2003, held in Helsinki, Finland in September 2003. The 12 revised full papers presented together with an extended abstract of an invited talk were carefully reviewed and selected from 25 submissions. Among the issues addressed are process modeling languages; computer-supported process description, analyses, reuse, refinement, and enactment; process monitoring, measurement, management, improvement, and evolution; and process enactment engines, tools, and environments.
Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.
This book constitutes the refereed proceedings of the 7th International Conference on Software Language Engineering, SLE 2014, held in Västerås, Sweden, in September 2014. The 19 revised full papers presented together with 1 invited paper were carefully reviewed and selected from 61 initial submissions. The papers observe software languages from different and yet complementary perspectives: programming languages, model driven engineering, domain specific languages, semantic web, and from different technological spaces: context-free grammars, object-oriented modeling frameworks, rich data, structured data, object-oriented programming, functional programming, logic programming, term-rewriting, attribute grammars, algebraic specification, etc.
Amyotrophic lateral sclerosis: Understanding and optimizing quality of life and psychological well-being presents a comprehensive and up-to-date review of the enhancement of the lives of people with amyotrophic lateral sclerosis (ALS) and their caregivers. ALS is a progressive, fatal neurodegenerative disorder. No current medical therapy can reverse or stop its progression, and the promotion of quality of life and psychological well-being is a central component of ALS care. Health care professionals who work in this field should incorporate attention to psychological, emotional, and relational aspects of the disease into their approach to care. This book provides some of the knowledge and direction necessary for optimizing the quality of care for individuals with ALS and their caregivers. Topics discussed include an ALS-centred view of quality of life, depressive features, anxiety, resilience, cognitive impairment, complementary and alternative medicines, and psychological research.