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Analyzing T Cell Responses
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated...
Systems Biology and Bioinformatics
The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods
Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It contains state-of-the-science reviews on invasion, metastasis, angiogenesis, apoptosis and immunologic aspects related to cancer.
Cancer Research
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Organelle and Molecular Targeting
We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile...
Wildlife Review
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Wildlife in a Changing World
"Wildlife in a Changing World" presents an analysis of the 2008 IUCN Red List of Threatened Species. Beginning with an explanation of the IUCN Red List as a key conservation tool, it goes on to discuss the state of the world s species and provides the latest information on the patterns of species facing extinction in some of the most important ecosystems in the world, highlighting the reasons behind their declining status. Areas of focus in the report include: freshwater biodiversity, the status of the world s marine species, species susceptibility to climate change impacts, the Mediterranean biodiversity hot spot, and broadening the coverage of biodiversity assessments."
