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Antibodies
Intended for specialists in B cell immunology, investigating such topics as movement of a monoclonal antibody from the laboratory into the clinic, the field of Fc receptors and the impact of monoclonal antibodies on diagnosis and treatment of human
The Antibodies
This book responds to dramatic current developments in molecular and cellular biology, and in the increasingly interrelated disciplines of genetics, immunology/immunotherapy and microbiology. Advances in molecular biology, genetic engineering, cloning and DNA sequencing have made it possible to model, design, and produce specific-purpose antibody molecules. This ability to alter molecular/protein structures, and even create new ''tailor-made'' molecules and proteins, is a quantum leap for both basic science and clinical medicine. The Antibodies: Volume 1 shows the applications of engineered antibodies in diagnosis immunotherapy, and protein purification, and provides new insights into the structural basis of antigen binding, effector functions, and regulation of the immune response. These therapeutic and practical uses of antibody engineering are possible by focusing on established as well as emergent concepts, methods, and techniques.
The Antibody Enigma
The Antibody Enigma is a somewhat personal view of the antibody diversity question from two investigators who have spent the past 18 years trying to penetrate the enigma. It is not and was not meant to be an all-embracing comprehensively referenced review of the subject of antibody diversity. Because of the subjective viewpoint, there are un doubtedly omissions of data that others consider to be seminal, and if we have offended anyone by omitting their own contribution we sin cerelyapologize. We have lived with "The Enigma" on and off for the past two years. It has been both hard work and good fun but, above all, it has been a learning experience. There were several difficult decisions to ma...
Antibodies
Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them, their properties and structural characteristics is still incomplete. The Antibodies: Volume 2 is a comprehensive review of topics of contemporary interest for specialists in B cell immunology. This volume investigates such topics as sequencing the variable regions of human antibodies directed against exogenous antigens; a review of the protective immune response; a review of the utilization of the VH4-34 (VH4-21) gene segment in normal, neoplastic and autoimmune repertoires; and a review of antigenized antibodies. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Antibodies
This book responds to dramatic current developments in molecular and cellular biology, and in the increasingly interrelated disciplines of genetics, immunology/immunotherapy and microbiology. Advances in molecular biology, genetic engineering, cloning and DNA sequencing have made it possible to model, design, and produce specific-purpose antibody molecules. This ability to alter molecular/protein structures, and even create new ''tailor-made'' molecules and proteins, is a quantum leap for both basic science and clinical medicine. The Antibodies: Volume 1 shows the applications of engineered antibodies in diagnosis immunotherapy, and protein purification, and provides new insights into the structural basis of antigen binding, effector functions, and regulation of the immune response. These therapeutic and practical uses of antibody engineering are possible by focusing on established as well as emergent concepts, methods, and techniques.
Immunologic Phylogeny
There are two now classic reasons for the widespread and con tinuing interest in the phylogeny of immune reactivities and structure. First is the fundamental concern of biologists with the evolution of defense mechanisms. We are eager to discover origins, mechanisms, and adaptive specializations of immunocompetence because the very existence of individuals and entire species is involved in a most essential way. Second is the strong biomedical interest in adaptive immune mechanisms to increase understanding of health and disease in man. If man and placental mammals represent the quin tessence of immunoresponsiveness with complex interdependent path ways, the less elaborate but fully functiona...
The Antibodies
From diagnostic tools to therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them is still incomplete. The Antibodies: Volume 7 continues with a comprehensive review of topics of contemporary interest including major breakthroughs such as the advent of monoclonal antibodies and the develo
