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Human CD38 and Related Molecules
In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observ...
Official Gazette
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Fundamentals of Molecular Similarity
In recent years the fundamental concepts and applied methodologies of molecular similarity analysis have experienced a revolutionary development. Motivated by the increased degree of understanding of elementary molecular properties on the levels ranging from fundamental quantum chemistry to the complex interactions of biomolecules, and aided by the spectacular progress in computer technology and access to computer power, the area has opened up to many new ideas and new approaches. This book covers topics in quantum similarity approaches, electron density shape analysis methods, and it provides better theoretical understanding of molecular similarity. Additionally, quantitative shape analysis...
Stromal Immunology
Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.
Epidermal Langerhans Cells
Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.
CONVIVIA FILTH
Convivia is a journal that is interested in thinking what architectonics is or could be in the twenty-first century. Pre-specific to architecture, architectonics deals with the real in an abstract, yet edifying manner. Under architectonics, the indeterminacy brought by contemporary science is assumed as a liberation from ontological and epistemological principles, and welcomed as a fortunate occasion to understand and embrace the stating of any principle as an ‘art’ in itself—autonomous, yet not automatic or autarkic. Architectonic deals with the real in terms of a communicational physics, through articulations that are concrete yet reasoned in abstractive and projective manners. The journal aims to set the table for a series of banquets—of convivia—in which courses do not respond to mere needs or inconsequential delights of ‘consumption’. We focus on architectonic alloys of necessities and contingencies: necessities are bounded by contingencies, and contingencies are engendered through ‘figuring out’ what is necessary. Convivia’s interest is to ‘make cases’.
Landslide Dynamics: ISDR-ICL Landslide Interactive Teaching Tools
This interactive book presents comprehensive information on the fundamentals of landslide types and dynamics, while also providing a set of PPT, PDF, and text tools for education and capacity development. It is the second part of a two-volume work created as the core activity of the Sendai Partnerships, the International Consortium of Landslides. The book will be regularly updated and improved over the coming years, based on responses from users and lessons learned during its application.
