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Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are act...
Every cell of the body is dependent on calcium to function. Calcium is found in teeth and bones, and calcium signalling is necessary for the movement of muscles and for the action of the heart and the intestines as well as blood coagulation. Calcium in Living Cells will update classic techniques in detecting microscopic levels of calcium ions (Ca2+) in living cells, as well as address new techniques in the field of calcium detection and calcium signaling. Such detection and measurement of intracellular calcium is important to researchers studying the heart, musculoskeletal, gastrointestinal, and immune systems, whose findings will aid in the advancement of drug and genomic therapies to treat...
Examines the history of All-Star baseball, providing play-by-plays, rosters, and box scores of each game; and discusses how All-Star games have been influenced by racial integration, expansion teams, and the designated hitter.
In 1974, a scientific conference covering marine automation group and large vessels issues was organized under the patronage of the Technical Naval Studies Centre (CETENA) and the Italian National Research Council (CNR). A later collaboration with the Marine Technical Association (ATENA) led to the renaming of the conference as NAV, extending the topics covered to the technical field previously covered by ATENA national conferences. The NAV conference is now held every 3 years, and attracts specialists from all over the world. This book presents the proceedings of NAV 2018, held in Trieste, Italy, in June 2018. The book contains 70 scientific papers, 35 technical papers and 16 reviews, and subjects covered include: comfort on board; conceptual and practical ship design; deep sea mining and marine robotics; protection of the environment; renewable marine energy; design and engineering of offshore vessels; digitalization, unmanned vehicles and cyber security; yacht and pleasure craft design and inland waterway vessels. With its comprehensive coverage of scientific and technical maritime issues, the book will be of interest to all those involved in this important industry.
Arguing about the merits of players is the baseball fan's second favorite pastime and every year the Hall of Fame elections spark heated controversy. In a book that's sure to thrill--and infuriate--countless fans, Bill James takes a hard look at the Hall, probing its history, its politics and, most of all, its decisions.
This set of two volumes comprises the collection of the papers presented at the 5th International Conference on Maritime Technology and Engineering (MARTECH 2020) that was held in Lisbon, Portugal, from 16 to 19 November 2020. The Conference has evolved from the series of biennial national conferences in Portugal, which have become an international event, and which reflect the internationalization of the maritime sector and its activities. MARTECH 2020 is the fifth of this new series of biennial conferences. The set comprises 180 contributions that were reviewed by an International Scientific Committee. Volume 1 is dedicated to maritime transportation, ports and maritime traffic, as well as maritime safety and reliability. It further comprises sections dedicated to ship design, cruise ship design, and to the structural aspects of ship design, such as ultimate strength and composites, subsea structures as pipelines, and to ship building and ship repair.
Contributions from worldwide experts showcase the power the IO community has to foster, promote and encourage pro social efforts. Also included will be commentary from an eminent group of IO psychologists who give invaluable insights into the history and the future of IO psychology .