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This work sets out to provide the information necessary for understanding endotoxin and its effects on the lungs, and explicates the difficulties in determining how to manipulate endotoxin pathobiology. The rationale for, and efficacy of, current and experimental treatments for sepsis, adult respiratory distress syndrome and other endotoxin-induced lung injuries are discussed.
Reflects the explosion of information and technological breakthroughs that have facilitated investigations into the development of the lung-including recombinant DNA technology, molecular genetics, transgenics, and advances in lung cell and mo-lecular biology. Provides nearly 2800 bibliographic citations and over 170 tables, drawings, and x-rays to help clarify specific discussions.
This book provides a comprehensive, authoritative, and contemporary discussion of the physiology and pathophysiology of the chest wall as well as an overview of the diagnostic and therapeutic modalities. It is an invaluable aid to clinical investigators.
Providing an up-to-date overview of the field, this state-of-the-art reference details how sleep and circadian rhythms are interconnected, revealing the impact of various disease states on, and the molecular and genetic basis for, disrupted sleep and circadian rhythmicity and their effects on physical and mental health, safety, performance, and pro
"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."
This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.
Why did "microbe hunters" at the Pasteur Institute become the most important health experts in the French empire in the early twentieth century? Pasteur's Empire illustrates how French microbiologists transformed life in the colonies in the name of humanitarian public health, which often had grave consequences for those living under French rule.
This reference offers detailed discussions of the basic aspects of signal transduction, and examines their applications in lung cell biology. Providing an overview of current research directions, Signal Transduction in Lung Cells covers: the structure and function of receptors; the structure and regulation of G proteins; second messenger systems including kinases and phosphatases; airway and alveolar cells; smooth muscle cells; inflammatory and immune cells; muscle tone, ion channels, growth factors and cytokines.;With over 1900 literature citations and figures, Signal Transduction in Lung Cells is intended as a resource for pulmonologists, physiologists, molecular and cell biologists, pharmacologists, and graduate and medical school students in these disciplines.
For nearly thirty years, anthropologist and physician Paul Farmer has traveled to some of the most impoverished places on earth to bring comfort and the best possible medical care to the poorest of the poor. Driven by his stated intent to "make human rights substantial," Farmer has treated patients—and worked to address the root causes of their disease—in Haiti, Boston, Peru, Rwanda, and elsewhere in the developing world. In 1987, with several colleagues, he founded Partners In Health to provide a preferential option for the poor in health care. Throughout his career, Farmer has written eloquently and extensively on these efforts. Partner to the Poor collects his writings from 1988 to 2009 on anthropology, epidemiology, health care for the global poor, and international public health policy, providing a broad overview of his work. It illuminates the depth and impact of Farmer’s contributions and demonstrates how, over time, this unassuming and dedicated doctor has fundamentally changed the way we think about health, international aid, and social justice. A portion of the proceeds from the sale of this book will be donated to Partners In Health.
Synthesizing disparate information into a readily accessible format, this insightful volume presents state-of-the-art reviews on the basic and clinical features of pulmonary diseases in HIV-infected individuals-informing critical decision making as well as suggesting avenues for future research. A beneficial compendium for those dealing with pulmonary complications of HIV infection, Human Immunodeficiency Virus and the Lung surveys current knowledge on the epidemiology of HIV infection examines HIV's effects on lung cells in addition to immune functions within the lung details individual pulmonary infections in terms of etiology, clinical presentation, diagnosis, treatment, and prophylaxis emphasizes the indications and limitations of various diagnostic techniques, including invasive and noninvasive testing and screening considers noninfectious pulmonary complications from neoplastic and inflammatory to immunological disorders advises on the management of individuals in intensive care with the aid of morbidity and mortality data assesses common recommendations as well as provides clear guidelines for preventing the transmission of infectious pathogens and more!