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A comprehensive history of the National Hospital, Queen Square, and its Institute, placed within the context of British neurology.
The latest research regarding the neurodegenerative conditions known as neuroacanthocytosis will be found in this book. Recent advances have identified the range of mutations in the causative genes. In vitro studies have identified potential protein interactions, and work on erythrocyte membranes suggests mechanisms for the generation of acanthocytes. Animal models are being generated and provide the foundation for possible therapeutic interventions.
Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.
"This is a fascinating, enjoyable book. It could well be used in study groups at the high school or college level to explore both history and attitudes toward deafness."--Rehabilitation Literature. "The editors are not enthralled, as so many of us seem to be, simply that deaf (or disabled) characters exist in literature; they ask why ... The rest of the disability movement could learn from them."--The Disability Rag. Dickens, Welty, and Turgenev are only three of the master storytellers in Angels and Outcasts. This remarkable collection of 14 short stories offers insights into what it means to be deaf in a hearing world. The book is divided into three parts: the first section explores works ...
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First multi-year cumulation covers six years: 1965-70.