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Regulation of Organelle and Cell Compartment Signaling
"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
Histone Deacetylases
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
Handbook of Cell Signaling
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Nuclear Signaling Pathways and Targeting Transcription in Cancer
At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in...
Chromatin and Chromatin Remodeling Enzymes Part C
DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the chromatin remodelling enzymes play an important role in gene transcription. - Genetic assays of chromatin modification and remodeling - Histone modifying enzymes - ATP-dependent chromatin remodeling enzymes
The Superintendent's Fieldbook
Guidance for ever-changing challenges, success through improved effectiveness Equip yourself to face the demands of a superintendent with this practical guide for new and veteran school leaders. Understanding leadership and budgets is only one piece of a pie that has grown to include privatization, performance- based teacher compensation, technology, and global comparisons like PISA. Based on 15 years of research with 300 superintendents, including members of the National Superintendents Roundtable, The Superintendents Fieldbook will become your touchstone for practical advice that you can implement today. The authors developed this new edition to help you Navigate difficult situations through sample cases and tips for action Lead with an eye on global impacts by illuminating education abroad Understand the Common Core standards as explained by fellow superintendents Explore instructional coaching and rounds as professional learning opportunities
New York City's Best Public High Schools
Providing everything parents need to know for helping to choose a high school for their child, this title includes interviews with teachers, parents and students and looks at atmosphere, homework, student stress, competition amongst students and the condition of the school buildings.
Reversible Protein Acetylation
A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.
Ethnographic Study of Marine Conservation
This book explores the nature of marine conservation based on the case study of Hinase, a fishing village in Okayama, Japan. It focuses on the fishers’ self-motivated eelgrass restoration activity which has been continued for more than 30 years. This activity in Hinase recently attracted international attention as a case under the name “Satoumi” and “Marine Protected Areas” in several governmental reports, but detailed information, such as the historical background and social structure of Hinase, has not yet been analyzed. This book, therefore, fulfills this gap by providing its ethnographic information. In addition, this book offers some points for critical thinking by concluding ...
The Oxford Guide to the Uralic Languages
This volume offers the most comprehensive and wide-ranging treatment available today of the Uralic language family, a group of languages spoken in northern Eurasia. While there is a long history of research into these languages, much of it has been conducted within several disparate national traditions; studies of certain languages and topics are somewhat limited and in many cases outdated. The Oxford Guide to the Uralic Languages brings together leading scholars and junior researchers to offer a comprehensive and up-to-date account of the internal relations and diversity of the Uralic language family, including the outlines of its historical development, and the contacts between Uralic and ...
