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Exploring Cancer Metabolic Reprogramming through Molecular Imaging
The inclusion of oncogene-driven reprogramming of energy metabolism within the list of cancer hallmarks (Hanahan and Weinberg, Cell 2000, 2011) has provided major impetus to further investigate the existence of a much wider metabolic rewiring in cancer cells, which not only includes deregulated cellular bioenergetics, but also encompasses multiple links with a more comprehensive network of altered biochemical pathways. This network is currently held responsible for redirecting carbon and phosphorus fluxes through the biosynthesis of nucleotides, amino acids, lipids and phospholipids and for the production of second messengers essential to cancer cells growth, survival and invasiveness in the...
Cancer Research
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World Cancer Day 2021: A Retrospective
Cancer accounts for millions of deaths every year, and the burden of this disease is striking - testing our families, health-care systems, economies, and our scientists. In recent years, the outstanding work of researchers and vast improvements in technology has led to remarkable strides in progress. We are now able to prevent at least one third of cancers and have adapted routine-screening techniques for early detection and effective treatment. Our ability to treat and manage this shape-shifting disease has also transformed, as we have developed sophisticated therapies and adopted more tailored approaches. As a result, survival rates are reaching new highs each year, and the outlook for tho...
AACR 2016: Abstracts 2697-5293
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
XX Secolo dopo Cristo Ubi Christianus?
Cento anni fa Luigi Trafelli, matematico e fisico nettunese, faceva stampare a sue spese in un’officina tipografica (Pistoia, 1917) e distribuiva gratuitamente ad un ristretto numero di interlocutori il suo primo saggio filosofico-religioso intitolato “XX Secolo dopo Cristo - Ubi Christianus? (Experimentum crucis)”. Questo libro, che sostiene con rigorosa logica l’inconciliabilità tra guerra e Cristianesimo, rappresenta una limpida e vibrante testimonianza del pensiero pacifista che fu attivo in Italia e in Europa nella prima metà del XX secolo. Tra gli altri aspetti più suggestivi del pensiero storico-filosofico del Trafelli si ravvisa la sua mirabile sintesi tra la fratellanza p...
Encyclopedia of Italian Literary Studies: A-J
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