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Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
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It was Faraday who in 1821 said that there are three necessary stages of useful research. The first to begin it, the second to· end it, and the third 1 to publish it. There has since indeed been so much research and publication that we have become increasingly alarmed by the galloping proliferation of scientific information produced in relation to the user's ability to retrieve and consume it effectively, conveniently and creatively. In 1948, to deal with this concern, the Royal Society Scientific Infor 1 mation Conference held in London spanned the whole realm of scientific in formation. Sir Robert Robinson, President of the Royal Society, in his open ing address noted that "the study of s...
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With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models.