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Pathophysiology of Bone and Mineral Metabolism
Bone is the principal store for calcium and phosphate and one of the main regulators of mineral metabolism. The principal cells involved in bone remodeling are osteocytes, osteoblasts and osteoclasts, which maintain a precise equilibrium of bone mass. However, there are many factors that can affect bone and mineral homeostasis such as inadequate diet, microbiota alterations or aging. Furthermore, pathological conditions such as renal diseases, genetic disorders, obesity or inflammatory diseases can also potentially affect bone homeostasis, compromising bone health and leading to fractures and complications. Thus, integration of the mechanisms involved in mineral and bone alterations is key to understand bone physiology and its endocrine functions.
Osteoarticular-immunological Interplay in Response to Disease and Therapy
Dr. Tomcik receives research funding from Arxx Therapeutics. The other Topic Editors declare no competing interests.
Innate Immunity in the Context of Osteoimmunology, 2nd Edition
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS. Part of the APCs for articles in this collection were financed by the Fondazione Beppe e Nuccy Angiolini ONLUS. Publisher’s note: In this 2nd edition, acknowledgment for the Fondazione Beppe e Nuccy Angiolini ONLUS has been added.
Principles of Bone Biology
Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previo...
A History of the University in Europe
A History of the University in Europe covers the development of the university in Europe (East and West) from its origins to the present day. No other up-to-date, comprehensive history of this type exists: its originality lies in focusing on a number of major themes viewed from a European perspective, and in its interdisciplinary, collaborative and transnational character. Volume 1, covering the Middle Ages, places the medieval European universities in their social and political context. After explaining the number and types of universities from their origins in the twelfth century to around 1500, it examines the inner workings as an institution and paints a general picture of medieval stude...
