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Protein Biosynthesis Interference in Disease
Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer's and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand...
Microbial Metabolism and Disease
Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer's dis...
Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery
Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome - metabolome - vagus nerve - brain circuit in Alzheimer's disease and associated diseases and medical conditions, including dementia, aging, COVID-19, and autoimmune conditions including rosacea. This volume also discusses the vagus nerve-related conditions including Arnold's reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in this book also address an important question: which one is more important for human health and intellectual abilities: the human genome or human mic...
Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis
Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases provides a detailed investigation into tryptamine, its underlying mechanisms, and metabolism across multiple diseases. The book explores key concepts of tryptamine, its biosynthetic pathways, and its influence in disease, specifically focusing on the Alzheimer's disease-associated gut bacterial sequence (ADAS). Various neurodegenerative conditions are covered alongside cancer, diabetes, infections, and chromosomal aberrations. Additionally, a chapter on gut tryptamine in domestic and agricultural animals is included. The book closes with case studies involving FDG-PET imaging in the context of tryptamine-treated mouse models and Alzheimer's disease patients. This book elucidates the implications of the gut microbiota-mediated tryptamine metabolism for human health, sharing insights into disease etiology, mechanisms, testing, prevention, and treatment. It is an ideal reference for researchers across the biomedical sciences.
Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis
Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases provides a detailed investigation into tryptamine, its underlying mechanisms, and metabolism across multiple diseases. The book explores key concepts of tryptamine, its biosynthetic pathways, and its influence in disease, specifically focusing on the Alzheimer's disease-associated gut bacterial sequence (ADAS). Various neurodegenerative conditions are covered alongside cancer, diabetes, infections, and chromosomal aberrations. Additionally, a chapter on gut tryptamine in domestic and agricultural animals is included. The book closes with case studies in...
Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery
Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer's disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold's reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human he...
Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and...
Landscapes of Time-Frequency Analysis
The chapters in this volume are based on talks given at the inaugural Aspects of Time-Frequency Analysis conference held in Turin, Italy from July 5-7, 2017, which brought together experts in harmonic analysis and its applications. New connections between different but related areas were presented in the context of time-frequency analysis, encouraging future research and collaborations. Some of the topics covered include: Abstract harmonic analysis, Numerical harmonic analysis, Sampling theory, Compressed sensing, Mathematical signal processing, Pseudodifferential operators, and Applications of harmonic analysis to quantum mechanics. Landscapes of Time-Frequency Analysis will be of particular interest to researchers and advanced students working in time-frequency analysis and other related areas of harmonic analysis.
Science for the Sustainable City
A presentation of key findings and insights from over two decades of research, education, and community engagement in the acclaimed Baltimore Ecosystem Study In a world of more than seven billion people—who mostly reside in cities and towns—the Baltimore Ecosystem Study is recognized as a pioneer in modern urban social-ecological science. After two decades of research, education, and community engagement, there are insights to share, generalizations to examine, and research needs to highlight. This timely volume synthesizes the key findings, melds the perspectives of different disciplines, and celebrates the benefits of interacting with diverse communities and institutions in improving Baltimore’s ecology. These widely applicable insights from Baltimore contribute to our understanding the ecology of other cities, provide a comparison for the global process of urbanization, and inform establishment of urban ecological research elsewhere. Comprehensive, interdisciplinary, and highly original, it gives voice to the wide array of specialists who have contributed to this living urban laboratory.
