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Regulation and targeting of enzymes mediating Parkinson’s disease pathogenesis: focus on Parkinson’s disease Kinases, GTPases and ATPases
Understanding the molecular pathogenesis of Parkinson’s disease (PD) is a priority in biomedical research and a pre-requisite to improve early disease diagnosis and ultimately to developing disease-modifying strategies. In the past decade and a half, geneticists have identified several genes that are involved in the molecular pathogenesis of PD. They not only identified gene variants segregating with familial forms of PD but also genetic risk factors of sporadic PD via genome-wide association studies (GWAS). Understanding how PD genes and their gene products function holds the promise of unraveling key PD pathogenic processes. Therefore the precise cellular role of PD proteins is currently...
Speaking with the Heart
Are you frustrated with having the same argument week after week? Do you act more like roommates than a couple who’s in love? Are you stuck not knowing what to do to change your connection, communication, and intimacy with your partner? We all want to have deeply connected relationships, but oftentimes, we become stuck in the same arguments and dynamics which keep us from experiencing the joy we wish to feel in our intimate relationships. Speaking with the Heart explains how communication is a love letter. The best conversations start with connection and compassion before any word is uttered. What is needed? What will help? Learning the powerful approaches outlined in the book can transform relationships. The key to effective communication for couples, at all stages, is tied to one core area that we were never taught: how to connect. It’s in understanding the power of making a simple shift from needing to be heard to wanting to connect with your partner—with every conversation—that could redefine how we approach communication in all of our relationships.
Leucine-Rich Repeat Kinase 2 (LRRK2)
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Parkinson's Disease
Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neuro...
City Culture and the Madrigal at Venice
Martha Feldman's exploration of sixteenth-century Venetian madrigals centers on the importance to the Venetians of Ciceronian rhetorical norms, which emphasized decorum through adherence to distinct stylistic levels. She shows that Venice easily adapted these norms to its long-standing mythologies of equilibrium, justice, peace, and good judgment. Feldman explains how Venetian literary theorists conceived variety as a device for tempering linguistic extremes and thereby maintaining moderation. She further shows how the complexity of sacred polyphony was adapted by Venetian music theorists and composers to achieve similar ends. At the same time, Feldman unsettles the kinds of simplistic align...
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson's Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the...
The Neuroscience of Parkinson's Disease
The Neuroscience of Parkinson's Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers the most comprehensive covera...
