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Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues
More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexpression has become a therapeutic target for overcoming multidrug resistance in tumors. However, P-gp is also expressed in cells of normal tissues where it plays a physiological role, by protecting them from the toxic effects of xenobiotics. Also, ABCB1 gene polymorphisms may influence the response to anticancer drugs substrate of P-gp. Several strategies to overcome P-gp tumor drug resistance have...
Gastrointestinal Cancers and Personalized Medicine
Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to "personalized cancer medicine". Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies. The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.
Australian Master GST Guide, 2011, 12th ed
The Australian Master GST Guide containsa clear, practical explanation of GST withnumerous examples of how it works inpractice. It is up to date to 1 January 2011 andincorporates all changes and all proposedchanges to the GST law. Particular attentionis given to key subject areas such as realproperty, imports/exports, finance, transport,food, education, health and charities.Significant coverage of audit, complianceactivities and planning opportunities is alsoincluded.
Deaf School
Liverpool has been a city of bands for decades, a dynamic center of musical innovation that gave the world one of the most iconic groups ever to grace popular music—The Beatles. Years later, in 1974, it nearly did it again. Rehearsing in the very same rooms that John Lennon did at the Liverpool College of Art, the band Deaf School formed, a chaotic and wildly entertaining group with a flair for rock cabaret. Avant-garde to the max, they were slated for instant stardom, signing with Warner Brothers. But the band would never have their heyday, lost in the vicissitudes of taste as Britain's punk rock revolution took hold, drowning their potential out. In Deaf School: The Non-Stop Pop Art Punk...
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Frontiers in Anti-Cancer Drug Discovery
“Frontiers in Anti-Cancer Drug Discovery” is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The fifth volume of the series features chapters on the following topics: -Nutraceuticals and natural food products for cancer treatment -Pharmacogenomics in Anti-cancer treatment -Cancer stem cells -Potassium channel targeting for brain tumor treatment -Sorafenib in the management of hepatocellular carcinoma …and more.
Rejuvenation Cruise
This is a fantasy adventure on board a cruise ship where cruise guests anticipate a cure for their infirmities from the healing waters of Paradise Island, the cruise ship destination. Select cruise guests are offered rejuvenation on board ship. On the island, the ship Captain discovers his origin. He leads his staff and crew in fulfilling their mission. Rejuvenated cruisers discover the concomitants of their rejuvenation.
Synergism and Antagonism in Chemotherapy
Practical, mechanism-oriented coverage of chemotherapeutic drug interactions in the clinic and in experimental model systems. Anticancer, antimicrobial, and antiviral systems are included, as well as methodology for characterization and quantization of synergism and antagonism. Annotation copyrighted by Book News, Inc., Portland, OR
