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RNA Nanotechnology and Therapeutics
Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.
RNA - Ligand Interactions, Part A: Structural Biology Methods
RNA-Ligand Interactions, Part A focuses on structural biology methods. Major topics covered include semisynthetic methodologies (RNA synthetic methods and derivatization of RNA); RNA structure determination (X-ray crystallography, NMR, EM); techniques for monitoring RNA conformation and dynamics (solution methods and electrophoretic and spectroscopic methods); and modeling tertiary structure: Part B, its companion Volume 318 of Methods in Enzymology, focuses on molecular biology methods.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the Series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Aminoglycoside Antibiotics
Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.
The Many Faces of RNA
The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.
Structure and Function of the Genetic Apparatus
The Fourth Course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held September 18-31, 1983 at the Ettore Majorana Center for Scientific Culture in Erice, Sicily. The subject of the Fourth Course, which was co-sponsored by national and international agencies, was "Structure and Function of the Genetic "Appara tus. " Participants from 15 countries around the world attended the course. The study of the genetic apparatus is one of humanity's most challeng ing problems, and it has been approached in the tradition of the School from many different points of view, among them biochemistry, genetic eng ineering, cell biology, oncology, biophysics a...
Nucleic Acid Switches and Sensors
This book reviews studies showing that interesting and useful molecular-scale switches and sensors can be made out of nucleic acids, by both artificial and natural means. The first section of the book is devoted to artificial nucleic acid switches and sensors. In second section, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist, in the evolution of natural nucleic acid switches and sensors.
The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment
MILS-14 provides a most up-to-date view of the exciting biogeochemistry of gases in our environment as driven mostly by microorganisms. These employ a machinery of sophisticated metalloenzymes, where especially transition metals (such as Fe, Ni, Cu, Mo, W) play a fundamental role, that is, in the activation, transformation and syntheses of gases like dihydrogen, methane, carbon monoxide, acetylene and those of the biological nitrogen and sulfur cycles. The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry and environmental biochemistry. All this is covered in an auth...
The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
One of Literary Hub's Most Anticipated Books of 2024 Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize–winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the “secret of life.” But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA—long overlooked as the passive servant of DNA—sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old...
Nucleic Acids from A to Z
Concise but complete, this mini-encyclopedia contains over 1,500 entries covering all important concepts, compounds, techniques and acronyms for quick and easy reference. Guiding readers through the ever-increasing jungle of nucleic acid science and technology, the book distills the key information out of the large body of primary literature and presents it in a single volume. A first-stop resource for everyone, from students to established researchers, as both a desktop and library reference.
Ribonuclease P
The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D st...
