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Current Challenges in Complement Diagnostics
The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolle...
Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases
Non-communicable diseases (NCDs) are chronic diseases that include most ageing-related diseases, representing the main cause of death and disability in the general population. Inflammation and oxidative stress are common features in NCDs, responsible for the cell, tissue, and organ damage that contributes to the progression of these diseases. They may be also key targets for the development of novel preventive and therapeutic strategies. This Special Issue includes 14 peer-reviewed papers, including 12 original research papers and 2 reviews. Together, they represent the most recent progress in the field of several degenerative disorders, aiming to establish specific biomarkers, detailing the pathogenesis and the evolution of these diseases, making a correct diagnosis, and opening up new therapeutic strategies. Of relevance, many studies report the beneficial effects of natural compounds, derived from several plants, leaves, and fruits; their antioxidant and anti-inflammatory properties suggest their use as a dietary supplement for prevention and/or complement to standard therapies.
Insights in Molecular Innate Immunity: 2022
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Immunology. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of Immunology in 2022. This editorial initiative of particular relevance, led by Prof. Francesca Granucci Specialty Chief Editor of the Molecular Innate Immunity section, and Dr. Uday Kishore is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of molecular innate immunity.
Collaborative Public Management
Local governments do not stand alone—they find themselves in new relationships not only with state and federal government, but often with a widening spectrum of other public and private organizations as well. The result of this re-forming of local governments calls for new collaborations and managerial responses that occur in addition to governmental and bureaucratic processes-as-usual, bringing locally generated strategies or what the authors call "jurisdiction-based management" into play. Based on an extensive study of 237 cities within five states, Collaborative Public Management provides an in-depth look at how city officials work with other governments and organizations to develop the...
Handbook of Crisis and Emergency Management
Including contributions from sixty international authors, this book examines emergency responses to environmental dangers such as chemical fires, hazardous material and oil spills, nuclear reactor accidents, and earthquakes, and crises in the environment, global public service, and politics. It covers a wide range of international issues and topics, using various analyses, including critical, descriptive, empirical, quantitative, and normative methods. The book discusses approaches to natural disasters, resolutions to cultural, religious, and political tensions, terrorism and the potential use of biological, chemical, and nuclear weapons, the role of crisis public relations, and more.
Governance in Modern Society
This book is the immediate result of the co-operation of a great number of scholars in the Netherlands Institute of Government (NIG). NIG is an interuniversity research school. As such it has a double task. In addition to offering a Ph.D program to students in Public Administration it also is a research institute in which a great number of scholars from seven Dutch universities participate and work on a common research program. The chapters in this book are all products of the research program that started in 1995. This program had the ambition to explore the frontiers of the discipline in two respects. First by studying a number of recent developments in society and their consequences for t...
Narratives of Low Countries History and Culture
This edited collection explores the ways in which our understanding of the past in Dutch history and culture can be rethought to consider not only how it forms part of the present but how it can relate also to the future. Divided into three parts – The Uses of Myth and History, The Past as Illumination of Cultural Context, and Historiography in Focus – this book seeks to demonstrate the importance of the past by investigating the transmission of culture and its transformations. It reflects on the history of historiography and looks critically at the products of the historiographic process, such as Dutch and Afrikaans literary history. The chapters cover a range of disciplines and approac...
Managing Complex Networks
Although the concept of policy networks is now well-established in the field, most research has to content itself with description and analysis of their contribution to policy failure. This book goes further. It accepts policy networks as a fundamental characteristic of modern societies and presents an overview of the strategies for the management of these networks, as well as illustrating the various strategies for intervention.
