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Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects
Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.Key Features* Organized and written by world-renowned experts* Covers state-of-the-art experimental methods* Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies
Chloride Channels
The amount of new information on the molecular biology of chloride channels has grown tremendously in recent years. This large amount of information gives some unique and, in some instances, surprising insights into the function and structure of chloride channels which are present in every cell. This volume contains a series of in-depth reviews of chloride channel physiology, biophysics, and molecular biology. The reviews cover chloride channels found in the plasma membrane as well as in organelles of both plant and animal cells.Key Features* Discusses CFTR, the cystic fibrosis transmembrane regulator, which is responsible for CF and the CIC-family of chloride channels responsible for myotonia congenita* In-depth reviews of chloride channel physiology, biophysics, and molecular biology* Reviews chloride channels found in the plasma membrane and in organelles of both plant and animal cells
Chemokines, Chemokine Receptors and Disease
This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research
The Geography of Bliss
The Geography of Bliss membawa pembaca melanglangbuana ke berbagai negara, dari Belanda, Swiss, Bhutan, hingga Qatar, Islandia, India, dan Amerika ... untuk mencari kebahagiaan. Buku ini adalah campuran aneh tulisan perjalanan, psikologi, sains, dan humor. Ditulis tidak untuk mencari makna kebahagiaan, tapi di mana. Apakah orang-orang di Swiss lebih bahagia karena negara mereka paling demokratis di dunia? Apakah penduduk Qatar, yang bergelimang dolar dari minyak mereka, menemukan kebahagiaan di tengah kekayaan itu? Apakah Raja Bhutan seorang pengkhayal karena berinisiatif memakai indikator kebahagiaan rakyat yang disebut Gross National Happiness sebagai prioritas nasional? Kenapa penduduk As...
Osmotic and Ionic Regulation
In the 40 years since the classic review of osmotic and ionic regulation written by Potts and Parry, there has been astonishing growth in scientific productivity, a marked shift in the direction and taxonomic distribution of research, and amazing changes in the technology of scientific research" It is indicative of the growth of the subject that as
Ion Mobility-Mass Spectrometry
Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.
Computational Modeling of Membrane Bilayers
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Discusses the current state of electrostatics in biomolecular simulations and future directions Includes information on time and length scales in lipid bilayer simulations Includes a chapter on the nature of lipid rafts
Ion Exchangers
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Basement Membranes: Cell and Molecular Biology
Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules. Reviews the early years of research and the discovery of type IV collagen Presents the diversity of basement membrane morphology Discusses gene structure
The Nociceptive Membrane
Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.
