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Mechanosensitive Ion Channels, Part B
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity o...
Mechanosensitive Ion Channels
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Tran...
Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects
Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors. Key Features * Organized and written by world-renowned experts * Covers state-of-the-art experimental methods * Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies
Chemokines, Chemokine Receptors and Disease
This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research
The Oxford Handbook of Danish Politics
The Oxford Handbook of Danish Politics provides the most comprehensive and thorough English language book on Danish politics ever written. It features chapters by 50 leading experts who have contributed extensively to the field they write about. Why is Denmark an interesting topic for a Handbook? In some respects, Danish political institutions and political life are very similar to that of other small, North European countries such as the other Scandinavian countries and Netherland. However, in other respects, Danish politics is interesting in its own right. For instance, Denmark has a world record in minority governments. According to standard scholarly knowledge, this should result in unst...
Chloride Channels
The amount of new information on the molecular biology of chloride channels has grown tremendously in recent years. This large amount of information gives some unique and, in some instances, surprising insights into the function and structure of chloride channels which are present in every cell. This volume contains a series of in-depth reviews of chloride channel physiology, biophysics, and molecular biology. The reviews cover chloride channels found in the plasma membrane as well as in organelles of both plant and animal cells. Key Features * Discusses CFTR, the cystic fibrosis transmembrane regulator, which is responsible for CF and the CIC-family of chloride channels responsible for myotonia congenita * In-depth reviews of chloride channel physiology, biophysics, and molecular biology * Reviews chloride channels found in the plasma membrane and in organelles of both plant and animal cells
Computational Modeling of Membrane Bilayers
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Discusses the current state of electrostatics in biomolecular simulations and future directions Includes information on time and length scales in lipid bilayer simulations Includes a chapter on the nature of lipid rafts
Chapter A Test Facility to Investigate Sheath Effects During Ion Cyclotron Resonance Heating
Nuclear fusion is a promising candidate to supply energy for future generations. At the high temperatures needed for the nuclei to fuse, ions and electrons are no longer bound into atoms. Magnetic fields confine the resulting plasma. One of the heating methods is the ion cyclotron resonant absorption of waves emitted by an external Ion Cyclotron Radio Frequency (ICRF) antenna. The efficiency of ICRF heating is strongly affected by rectified RF electric fields at antenna and other in-vessel components (so-called 'sheath effects'). The chapter presents an overview of ICRF principles. Attention is given to characterising the detrimental sheath effects through experiments on a dedicated test facility (IShTAR: Ion cyclotron Sheath Test ARrangement). IShTAR has a linear magnetic configuration and is equipped with an independent helicon plasma source. The configuration and capabilities of the test-bed and its diagnostics are described, as well as an analysis of the plasmas.
Current Topics in Membranes
This title contains comprehensive reviews of novel information in intestinal transport, including control of nutrition in gene regulation. There are diagrammatic representations of key concepts and processes. Additionally, this volume offers new insight at a molecular level into the basis of intestinal disease. The topics covered in this book also relate to other epithelial organs such as the lungs, kidney, and biliary system.
