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Although it is the defining organ of the Chordata, the notochord and its cells are one of the least understood vertebrate organs. This may be because large parts of the notochord are often replaced with cartilaginous or bony vertebral bodies. The presence of cartilage in the notochord raises questions about the evolutionary relationships between notochord cells and cartilage cells. This book integrates classical analytical studies with recent palaeontological, experimental, and molecular studies in both developmental and evolutionary contexts. For example, although the early signaling function of the notochord is conserved across the vertebrates, many will be surprised to find that the role ...
In an instant, Brittany Yardin’s view in the mirror changed forever. A tragic accident as a preteen left permanent physical scars, but teasing by the mean girl clique left deeper emotional ones. Years later, Brittany has made a life for herself on a tiny remote island, and the last person she expects to run into is high school mean girl and secret crush, Amy Jansons. Amy, aka Erika James, longs to be more than just a pretty face. As a top fashion model her beauty is the benchmark most women long to attain. She travels the world and wears the latest designer clothes, but as her fortieth birthday approaches, so does the end of her career, and she’s determined to keep her place at the top. When Amy needs help during a shoot, Brittany puts the past aside and friendship blooms. But so does the attraction neither of them can deny, and life on a remote island is no place for a serious model trying to save her career.
Fame and money rained down on Dess Hampton like a monsoon. She couldn’t imagine needing more—until her golden voice was silenced. Now her quiet days are filled with her guitar and she savors every sunrise. Curious, and as a favor to a friend, she emerges to hear a rumored superstar in the making. Music pours out of Erika Alvarez through her voice and her fingertips. She’s awed that the reclusive Dess Hampton wants to hear her sing, and then blown away when Dess agrees to sit in for a few gigs. Dess can tell that Erika is destined for the life that she once had and wants no part of, ever again. But can the magic of the music they make together, and the growing love between them, trump Erika’s ambition and Dess’s fears? How much are they willing to sacrifice for it—and for each other?
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologie...