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Chromosome Damage and Repair
The NATO - EMBO Advanced Study Institute - Lecture Course on "CHROMOSOME DAMAGE AND REPAIR" was held at God¢ysund Fjord Hotel outside Bergen, Norway. from Ms\r 27th to June 5th, 1980. This book represents the proceedings of this meeting. In addition to the for mal lectures, a number of short contributions presented in the dis cussion sessions following the lectures are also included. The papers have been divided into different groups according to topic, essentially in the same way as they were presented during the meet ing. The editors have m. ade' few alterations in the manuscript sub mitted and these were mostly confined to typing style and correc tion ot typographical errors. We would li...
Progress in Nucleic Acid Research and Molecular Biology
Progress in Nucleic Acid Research and Molecular Biology
Aging at the Molecular Level
During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
NASA Technical Paper
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Genomic Uracil: Evolution, Biology, Immunology And Disease
This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, repli...
DNA Repair Mechanisms
DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repa...
The Implicit Genome
For over half a century, we have been in the thrall of the double-helicaln structure of DNA, which, in an instant, revealed that information can be transferred between generations by a simple rule, A pairs with T, G pairs with C. In its beautiful simplicity, this structure, along with the table of codons worked out in the following decade, had entranced us into believing that we can fully understand the information content of a DNA sequence, simply by treating it as text that is read in a linear fashion. While we have learned much based on this assumption, there is much we have missed. Far from a passive tape running through a reader, genomes contain information that appears in new forms whi...
DNA Repair and Mutagenesis
An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
