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Leishmaniasis: From Innate and Adaptive Immunity to Vaccine Development
The parasitic disease leishmaniasis in its various clinical manifestations from self-resolving skin lesion to deadly systemic infection is a serious health problem in many developing countries and is considered to be a neglected tropical disease by the World Health Organization. To date, a vaccine is lacking and strategies to treat severe forms of leishmaniasis efficiently are missing. Basic research using animal models of experimental visceral or cutaneous leishmaniasis has allowed to dissect the immune response to parasitic pathogens and has contributed substantially to many important, paradigm-changing insights such as the role of cytokines in helper T-cell differentiation and the impact ...
Epitope Discovery and Synthetic Vaccine Design
Since variolation, conventional approaches to vaccine development are based on live-attenuated, inactivated or purified pathogen-derived components. However, effective vaccines against global health threats such as HIV, parasite infections and tumors are difficult to achieve. On the other hand, synthetic vaccines based on immunogenic epitopes offer advantages over traditional vaccines since they are chemically defined antigens free from deleterious effects. Additionally, in contrast to live-attenuated vaccines, they do not revert to virulence in immunocompromised subjects, and different from genetic vaccines, they do not involve ethical questions. Traditional vaccines contain PAMPs and induc...
Of Wonders and Wise Men
In the tumultuous decades following Mexico's independence from Spain, religion provided a unifying force among the Mexican people, who otherwise varied greatly in ethnicity and socioeconomic status. Accordingly, religion and the popular cultures surrounding it form the lens through which Terry Rugeley focuses this cultural history of southeast Mexico from independence (1821) to the rise of the dictator Porfirio Díaz in 1876. Drawing on a wealth of previously unused archival material, Rugeley vividly reconstructs the folklore, beliefs, attitudes, and cultural practices of the Maya and Hispanic peoples of the Yucatán. In engagingly written chapters, he explores folklore and folk wisdom, urban piety, iconography, and anticlericalism. Interspersed among the chapters are detailed portraits of individual people, places, and institutions, that, with the archival evidence, offer a full and fascinating history of the outlooks, entertainments, and daily lives of the inhabitants of southeast Mexico in the nineteenth century. Rugeley also links this rich local history with larger events to show how macro changes in Mexico affected ordinary people.
Immune evasion strategies in protozoan-host interactions
The protozoa are the most ancient members of the animal kingdom and they have evolved the intracellular parasitism to ensure their survival strategies. Protozoan parasites that infect humans are extremely diverse among eukaryotes. They are responsible for many human diseases such as amebiasis, Chagas disease, malaria, toxoplasmosis, leishmaniasis and African sleeping sickness. The ability of protozoans to cause disease depends on the nature and number of infecting organisms, the route of infection, the virulence factors associated with the microorganism, and the strength of host defenses. This host-parasite interaction is also subject to constant change as the infection proceeds and can lead...
Immunobiology of Leishmaniasis
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Leishmaniasis
Of all the parasitic diseases, leishmaniasis is one of the most diverse, with a variety of manifestations, from relatively minor cutaneous lesions to deadly visceral infections. It is also widespread, causing human disease in the Americas, Asia, Europe and Africa. The environments in which this disease occurs range from desert to tropical jungle to urban habitats. Not surprisingly, the literature on this disease is written in a variety of languages including Portuguese, Arabic, English and French among others. This book provides a synopsis in English of much of the recent research on leishmaniasis, with a focus on the epidemiology, diagnosis and treatment of the disease as described by researchers around the world, but with a focus on the research from Brazil and the Middle East.
Yucatán's Maya Peasantry and the Origins of the Caste War
Conflicts between native Maya peoples and European-derived governments have punctuated Mexican history from the Conquest in the sixteenth century to the current Zapatista uprising in Chiapas. In this deeply researched study, Terry Rugeley delves into the 1800-1847 origins of the Caste War, the largest and most successful of these peasant rebellions. Rugeley refutes earlier studies that seek to explain the Caste War in terms of a single issue. Instead, he explores the interactions of several major social forces, including the church, the hacienda, and peasant villagers. He uncovers a complex web of issues that led to the outbreak of war, including the loss of communal lands, substandard living conditions, the counterpoise of Catholicism versus traditional Maya beliefs, and an increasingly heavy tax burden. Drawn from a wealth of primary documents, this book represents the first real attempt to reconstruct the history of the pre-Caste War period. In addition to its obvious importance for Mexican history, it will be illuminating background reading for everyone seeking to understand the ongoing conflict in Chiapas.
