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The Chaperonopathies
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; gen...
Prokaryotic Cell Wall Compounds
Microbial cell wall structures play a significant role in maintaining cells’ shape, as protecting layers against harmful agents, in cell adhesion and in positive and negative biological activities with host cells. All prokaryotes, whether they are bacteria or archaea, rely on their surface polymers for these multiple functions. Their surfaces serve as the indispensable primary interfaces between the cell and its surroundings, often mediating or catalyzing important interactions. Prokaryotic Cell Wall Compounds summarizes the current state of knowledge on the prokaryotic cell wall. Topics concerning bacterial and archaeal polymeric cell wall structures, biological activities, growth and inhibition, cell wall interactions and the applications of cell wall components, especially in the field of nanobiotechnology, are presented.
Monoclonal Antibodies against Bacteria
Monoclonal Antibodies against Bacteria, Volume I explores the generation, characterization, and utilization of monoclonal antibodies against bacteria and on other monoclonal products relevant to antibacterial immune responses. Organized into 12 chapters, this book begins with a discussion on monoclonal antibodies against bacteria, encompassing its scope, research, and directions. It shows that the coordinated use of antisera and panels of monoclonal antibodies is proving useful for classification as a diagnostic tool with prognostic implications in the case of pathogens, or as a preliminary step in taxonomy. Also, monoclonal antibodies hold great potential as instruments in working with bact...
The multitasking molecular chaperone Hsp60
The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of...
Bacterial Diversity and Systematics
Bacterial taxonomy as a specialized discipline is practised by a minority but the applications of taxonomy are important to most, if not all microbiologists. It is the implementation of taxonomic ideas and practises which gives rise to identification and typing systems, procedures for the analysis and characterization of biodiversity, hypotheses about the evolution of micro-organisms, and improved procedures for the isolation and implementation of bacteria in biotechnological processes. Without taxonomic theory providing a sound basis to these many facets of microbiology there would be severe problems faced by many scientists working with micro-organisms. Taxonomy comprises three sequential ...
Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects
This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
Transportation Biofuels
Current world fossil oil production is struggling to meet demand and may even show a decline after 2010. It is therefore necessary to develop new energy-efficient production pathways for transportation biofuels. This book offers an insight into three promising and innovative pathways for the biological production of ethanol, biogas and biodiesel. These unconventional methods should provide higher product yields, less stringent feedstock specifications, lower chemical additive demand, reduced waste production and much better energy balances when compared to more traditional methods. One pathway concerns the enzymatic production of a new kind of biodiesel where no glycerol waste is produced an...
Molecular Microbial Ecology Manual
For a long time microbial ecology has been developed as a distinct field within Ecology. In spite of the important role of microorganisms in the environment, this group of 'invisible' organisms remained unaccessable to other ecologists. Detection and identification of microorganisms remain largely dependent on isolation techniques and characterisation of pure cul tures. We now realise that only a minor fraction of the microbial com munity can be cultivated. As a result of the introduction of molecular methods, microbes can now be detected and identified at the DNA/RNA level in their natural environment. This has opened a new field in ecology: Molecular Microbial Ecology. In the present manua...
(Endo)symbiotic Methanogenic Archaea
This updated monograph deals with methanogenic endosymbionts of anaerobic protists, in particular ciliates and termite flagellates, and with methanogens in the gastrointestinal tracts of vertebrates and arthropods. Further chapters discuss the genomic consequences of living together in symbiotic associations, the role of methanogens in syntrophic degradation, and the function and evolution of hydrogenosomes, hydrogen-producing organelles of certain anaerobic protists. Methanogens are prokaryotic microorganisms that produce methane as an end-product of a complex biochemical pathway. They are strictly anaerobic archaea and occupy a wide variety of anoxic environments. Methanogens also thrive in the cytoplasm of anaerobic unicellular eukaryotes and in the gastrointestinal tracts of animals and humans. The symbiotic methanogens in the gastrointestinal tracts of ruminants and other “methanogenic” mammals contribute significantly to the global methane budget; especially the rumen hosts an impressive diversity of methanogens. This makes this updated volume an interesting read for scientists and students in Microbiology and Physiology.
