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This practical reference provides thorough and systematic coverage on both basic metallurgy and the practical engineering aspects of metallic material selection and application.
Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular f...
This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. - This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases - The contributions in this volume cover the broad scope of methods in the research on these enzymes
The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous r...
Annotation Examines the factors that contribute to overall steel deformation problems. The 27 articles address the effect of materials and processing, the measurement and prediction of residual stress and distortion, and residual stress formation in the shaping of materials, during hardening processes, and during manufacturing processes. Some of the topics are the stability and relaxation behavior of macro and micro residual stresses, stress determination in coatings, the effects of process equipment design, the application of metallo- thermo-mechanic to quenching, inducing compressive stresses through controlled shot peening, and the origin and assessment of residual stresses during welding and brazing. Annotation c. Book News, Inc., Portland, OR (booknews.com)
About the Series This important new series of five volumes has been written with both the professional engineers and the academic in mind. Christian Lalanne explores every aspect of vibration and shock, two fundamental and crucially important areas of mechanical engineering, from both the theoretical and practical standpoints. As all products need to be designed to withstand the environmental conditions to which they are likely to be subjected, prototypes must be verified by calculation and laboratory tests, the latter according to specifications from national or international standards. The concept of tailoring the product to its environment has gradually developed whereby, from the very st...
This book presents the unified fatigue life prediction equation for low/medium/high cycle fatigue of metallic materials relevant to plain materials and notched components. The unified fatigue life prediction equation is the Wöhler equation, in which the "stress-based intensity parameter" is calculated based on the linear-elastic analysis. A local approach for the static fracture analysis for notched components is presented based on the notch linear-elastic stress field. In the local approach, a stress intensity parameter is taken as a stress-based intensity parameter. Experimental verifications show that the local approach is also suited for the static fracture analysis for notched componen...
This book discusses the theory, applicability and numerous examples of Miles’ equation in detail. Random vibration is one of the main design drivers in the context of the design, development and verification of spacecraft structures, instruments, equipment, etc, and Miles’ equation provides a valuable tool for solving random vibration problems. It allows mechanical engineers to make rapid preliminary random response predictions when the (complex) structure is exposed to mechanical and acoustical loads. The book includes appendices to support the theory and applications in the main chapters.