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Molecular Biology of B Cells
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
Mechanisms of Lymphocyte Activation and Immune Regulation III
Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in reper...
Current Concepts in Autoimmunity and Chronic Inflammation
The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result...
Making Science Fun – A Tribute to Our Colleague and Friend, Prof. Antonius G. Rolink (1953–2017)
This Research Topic honors the memory of Prof. Antonius “Ton” G. Rolink (April 19, 1953–August 06, 2017), our colleague, mentor and friend in immunology. It is now over a year since Ton left us. This article collection, authored by many of Ton’s friends and colleagues, reflects the huge contribution to cellular and molecular immunology that work emanating directly from Ton’s own hands and laboratory have made to the understanding of lymphocyte development. Ton’s hard work, expertise, generosity, passion for science and infectious humor were legendary and for all of those lucky enough to have been his colleague, he ensured that science was fun. We take this opportunity of thanking...
The Immune Response to Infection
Examines the mechanisms of both the innate and adaptive immune systems as they relate to infection and disease. • Explores the underlying mechanisms of immunity and the many sequelae of host-pathogen interactions, ranging from the sterile eradication of the invader, to controlled chronic infection, to pathologic corollaries of the host-pathogen crosstalk. • Discusses the pathogenesis of certain autoimmune disorders and cancers that are induced by infectious agents but then become independent of the infection process. • Serves as a resource for immunologists, molecular microbiologists, infectious disease clinicians, researchers, and students.
Advances in Immunology
For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researchers and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.Advances in Immunology will keep you informed on such broadly defined subjects as: - Immunochemistry - Antibody synthesis - Biological action of antibodies - Immunological unresponsiveness - Mechanisms in innate and acquired immunity not involving antibodies - Specialized immunological techniques
Molecular Biology of B-Cell and T-Cell Development
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cell...
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.
The Molecular Basis of B-Cell Differentiation and Function
The progress in protein and nucleic acid chemistry together with improvements of the previously employed tissue culture techniques have led to the solution of problems such as that of the generation of antibody diversity or of the molecular structure of T and B cell membrane receptor for antigen which had challenged the past generations of immunologists. Thanks to this progress an impressive amount of knowledge has been accumulated on certain cell types that were relatively "mysterious" until recently. The B lymphocyte represents a typical example of such a cell. With these considerations in mind, we have started to organize a NATO summer school on "The molecular basis of B cell differentati...
Immunoglobulin Genes
Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells.
