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This volume examines the role of steroids and peptides in the regulation of pregnancy and pregnancy outcome, and their long-term effects including possible influences on adult-onset diseases. During pregnancy the placenta acts as a central regulator and coordinator of maternal and fetal physiology, and the onset of labor, through its production and regulation of steroids and peptides. Perturbations to this regulatory system can result in poor pregnancy outcome, such as preterm birth and low birth weight. These in turn are linked to diseases in later life. Intriguingly, many of these regulatory actions of steroids and peptides also occur in the brain. The induction and suppression of peptides by steroids appears to be key to regulatory function in both brain and placenta. These interweaving strands, linking basic science with obstetrics, are all reviewed in depth here producing a fascinating account of an important area of materno-fetal medicine.
This two-volume book provides the first comprehensive survey of opioid research, a field which has accumulated a tremendous amount of literature since the identification of opioid receptors and their endogenous ligands. In more than 60 chapters experts present state-of-the-art reviews of this fascinating field, the topics ranging from molecular biology to clinical applications. Part I covers the multiplicity of opioid receptors, the chemistry of opiates and opioid peptides as well as the neurophysiology of opioids. Part II reviews a broad spectrum of physiological and behavioral functions and pharmacological actions of opioids, together with their neuroendocrinology, opioid tolerance and dependence, concluding with pathophysiological aspects and clinical use.
International Review of Neurobiology
Proceedings held April 1988. A comprehensive reference work on the most important recent advances in traditional areas of perinatology which gives special attention to interdisciplinary aspects. Subjects covered include: congenital abnormalities, nutrition, infections, new technologies, endocrinology, neurological development, renal pathology, perinatal monitoring, respiration, pharmacology and pharmacodynamics, exercise, sport and travel, cardiovascular pathophysiology, management of the under 1 kg baby, hypertension in pregnancy and initiation of labor. Annotation copyrighted by Book News, Inc., Portland, OR
Reports research results over a wide range of recent clinical investigations within the field of gynaecology and obstetrics. Over 300 authors from more than ten different countries provide data from current research programmes.
In the first section of this volume, we have attempted to bring together some of the papers that reflect exciting new areas of development in relation to neuroendocrine investigation. Very recently, specific nucleotide recognition sequences for thyroid hormones, steroid hormones and the fundamental intracellular regulator, cyclic AMP, have been determined. In this section, the preliminary characterization and investigation of the nuclear binding proteins that mediate the actions of cAMP are described. Not only does this represent an important advance in cell biology, but it may represent a further level of alteration in control in normal and disease states. Intercellular pituitary "cross tal...
With contributions by numerous experts